IV Anesthetics (Ch. 9)

Question 1

Ketamine (Ketalar)
receptor
onset
duration
effects on heart, resp, CNS
contraindications

Answer 1

NMDA receptors
onset: 1-2min
duration: 30-120min
heart: HTN, tachycardia, increase SVR, C.O., COMR
Resp: bdilation, increase secretions
CNS: increase CPP, ICP, prevents grandmal seizures, increase COMR
side effects: delirium
contraindications: HTN, CHF, CAD

Question 2

Etomidate
receptor
postop issues
onset

Answer 2

GABAa = increasing Cl
pain on injection. hypnotic 
PONV, DVT
onset: 30-60sec
no histamine release
CVS: minimal effect
RESP: mild \/ breathing
CNS: \/ COMR, ICP, CPP
myoclonus.
good for TBI
fentanyl prolongs etomidate

Question 3

Propofol (Diprivan)
receptor
components
CVS, Resp, CNS

Answer 3

GABAa = /\ Cl
lecithin (egg yolk)
CVS: \/BP, SVR, HR, Preload
RESP: ++\/ resp drive = apnea
CNS: \/CPP and ICP
antiemetic
antipruritic
anticonvulsants

Question 4

Dexmedetomidine (Precedex)
receptor
can treat

Answer 4

A2 Agonist
sedation, anxiolytic
TX: alcohol withdrawal, cocaine intoxication side effects