Cholinesterase Inhibitors (Ch. 12)

Question 1

Neostigmine
characteristics
dose
onset
duration
side effects

Answer 1

Lipid insoluble - cannot pass the BBB
0.08 mg/ml (max 5mg in adults)
onset: 5-10min
duration: 1 hour
used with 0.2mg of Glyco
-> fetal bradycardia (crosses the placenta)
also used to treat MG, urinary bladder atony, paralytic ileus

Question 2

Sugammadex
how it works
dose: 4-8 mg/kg
possible side-effects

Answer 2

modified gamma-cyclodextrin
hydrophobic cavity & hydrophilic exterior -> traps Roc in donut hole (cavity) = inactivating it
* expensive
hypersensitivity and allergic reactions