IV anaesthetic drugs

Question 1

MOA of propofol

Answer 1

GABA receptor agonist
(GABA- inhibitory compound)

Question 2

2 pros of using propofol

Answer 2

• rapid onset on anaesthesia
• anti-emetic

Question 3

2 cons of using propofol

Answer 3

-rapidly metabolised (with little accumulation of metabolites)
- moderate myocardial depression (hypotension)

Question 4

MOA of sodium thiopentone

Answer 4

GABA R agonist

Question 5

drug of choice for rapid induction and why

Answer 5

sodium thiopentone
- because highly lipid soluble so quickly affects the brain

Question 6

5 negatives of sodium thiopentone

Answer 6

• rapid build up of metabolites
• myocardial depression
  -little analgesic effect
  -unsuitable for maintainence infusion
  -laryngospasm

Question 7

ketamine MOA

Answer 7

NMDA receptor antagonist

Question 8

when can ketamine be used

Answer 8

induction of anaesthesia

Question 9

3 pros of ketamine

Answer 9

-strong analgesic
-little myocardial depression (no hypotension)
-can be used in trauma

Question 10

1 con of ketamine

Answer 10

may induce dissociative anaesthesia resulting in nightmares

Question 11

1 pro of etomidate

Answer 11

cardiac safety - little haemodynamic instability / used in haemodynamic instability

Question 12

4 cons of etomidate

Answer 12

-no analgesic properties
-adrenal suppression
-unsuitable for maintaining sedation
-post-op vomiting is common

Question 13

4 IV anaesthetic drugs

Answer 13

propofol
sodium thiopentone
ketamine
etomidate