drugs affecting muscles

Question 1

what are the 4 muscle relaxant (neuromuscular blocking )drugs

Answer 1

suxamethonium
atracurium
vecuronium
pancuronium

Question 2

mechanism of action of suxamethonium

Answer 2

binds to nicotinic Ach R which results in depolarisation causing generalised muscle contraction before paralysis
- fastest onset, shortest DOA

Question 3

DOA of atracurium

Answer 3

30-45 min

Question 4

DOA of vecuronium

Answer 4

30-40 min

Question 5

DOA of pancuronium

Answer 5

up to 2 hours

Question 6

MOA of atracurium, vecuronium , pancuronium

Answer 6

competitive antagonist of nicotinic Ach R

Question 7

3 adverse effects of suxamethonium

Answer 7

malignant hyperthermia
hyperkalemia
increases intra-ocular pressure (CI in narrow angle glaucoma, eye injury)

Question 8

1 adverse effects of atracurium, vecuronium , pancuronium and how to reverse their action

Answer 8

hypotension
- acetylecholine esterase inhibitors (neostigmine)

Question 9

muscle relaxant for rapid induction for intubation

Answer 9

suxamethonium (aka succinylcholine)