Isolated IgG subclass deficiency Flashcards
1
Q
Ab situation
A
Low/non-existant IgG, every other isotype is fine
2
Q
caused by
A
defects in several genes
3
Q
symptoms
A
asymptomatic
4
Q
Distribution of IgG2 vs IgG4
A
IgG2 frequently low in children with diagnosis
5
Q
associate with ____ infections
A
recurrent viral, bacterial infections involving respiratory tract
6
Q
IgG1
A
3+ Complement fixing ability
2+ transplacental transfer
7
Q
IgG2
A
1+ complement ability 1+ transplacental transfer
8
Q
IgG3
A
4+ complement ability, 2+ transplacental
9
Q
IgG4
A
0 complement ability, 2+ transplacental
