Common Variable Immune Deficiencies Flashcards
1
Q
CVID mutations effect what developmental stage?
A
Mature B cell –> Plasma cell stage
2
Q
What would be present in high numbers if CVID were diagnosed?
A
CD19 cell marker
3
Q
What illness is CVID associated with?
A
hypogammaglobulinemia
4
Q
CVID may be ______ or _____
A
inherited or acquired
5
Q
which genders are effected?
A
both male and female
6
Q
what is the Ab situation?
A
normal/low IgM but LOW IgG or IgA
7
Q
age of diagnosis:
A
around 2 years (but can be in 20s or 30s)
usually onset around 4-5 years of age
8
Q
Which aspect of hypoagammaglobulinemia is inherited and which is acquired?
A
Inherited: defects in B cell formation
Acquired: Abs against B cells (immune targeting)
9
Q
All CVID cases are susceptible to
A
recurrent bacterial infections
