HIGM

Question 1

what?

Answer 1

High IgM, low IgG/IgA

complement activation can occur

Question 2

What effector mechanisms would we NOT see in this situation?

Answer 2

Fc receptor dependent phagocyte response

neonatal immunity (so a baby would be effected because its mother itsnt producing IgG)

higher than normal helminth infections (eosinophil mediated)

immediate hypersensitivity

Question 3

How would hyper IgM be characterized?

Answer 3

impaired somatic hypermutation and Ig class switching

Question 4

x linked HIGM =

Answer 4

mutations in the Cd40L gene

CD40L on T cells interacts with CD40 on B cells stimulating terminal differentiation (class switching and somatic hypermutation)

Question 5

autosomal HIGM

Answer 5

1/3 cases of CD40 deficiencies

Question 6

What role do T cells play in this condition?

Answer 6

T cells provide CD40L stimulation, so if there’s a problem on either side, B cell proliferation and differentiation will not occur