Ischaemia and Infarction Pathophysiology Flashcards
1
Q
Types of hypoxia
A
Hypoxic
Anaemia
Stagnant
Cytotoxic
2
Q
Effects of ischaemia
A
Functional General Biochemical Cellular Clinical
3
Q
Clinical consequences of ischaemia
A
MI TIA Cerebral infarction Abdominal aortic aneurysm Peripheral vascular disease Cardiac failure
4
Q
Outcomes of ischaemia
A
No clinical effect
Resolution vs. therapeutic intervention
Infarction
5
Q
Factors affecting oxygen supply
A
Inspired O2 Pulmonary function Blood constituents Blood flow Integrity of vasculature e.g. atheroma/embolus/tumour Tissue mechanisms
6
Q
Factors affecting oxygen demand
A
Tissue itself: different tissues have different oxygen requirements
Activity of the tissue above baseline value
7
Q
Scale of damage of ischaemia/infarction dependent on several factors:
A
Time period
Tissue/organ
Pattern of blood supply
Previous disease
8
Q
Types of infarct
A
Coagulative necrosis e.g. heart, lung (most common)
Colliquitive necrosis e.g. brain
9
Q
End results of infarct
A
Scar replaces area of damaged tissue
Shape depends on territory of occluded vessel
Reperfusion injury
10
Q
MI repair processes
A
Cell death Acute inflammation Macrophage phagocytosis of dead cells Granulation tissue Collagen disposition (fibrosis) Scar formation
