ISBB - Other Blood Group Flashcards
Produced by tissue cells and found in secretions
ISBT 007 / Lewis
Not well developed at birth
ISBT 007 / Lewis
Identify if Le (a-b-) is newborn, nonsecretor, or true Lewis phenotype
newborn
Identify if Le (a+b-) is newborn, nonsecretor, or true Lewis phenotype
nonsecretor
Identify if Le (a-b+) is newborn, nonsecretor, or true Lewis phenotype
true Lewis phenotype
Unique because ___ antigens are not intrinsic to RBCs but are type 1 glycosphingolipids that are passively absorbed on the RBC membrane plasma
ISBT 007 / Lewis
♥ Le (a-b-): found more frequently among ___
♥ _____: rare among whites and Africans but is more frequent among Asians
♥ _____: always present on nonsecretors; Lewis nonsecretor phenotype
♥ Africans
♥ Le (a+b+)
♥ Le(a)
Lack of expression of Lewis antigens has been demonstrated on the RBCs of patients with ___, ___, ___, ___
Cancer
Alcoholic
Cirrhosis
Viral and parasitic infections
Lewis causes mild ___; do not cause ___
HTR; HDN
ISBT 007
Lewis
ISBT 003
P1PK
P1PK: In their search for new antigens, they injected rabbits with human RBCs and produced an antibody, initially called ___, that divided human RBCs into two groups: ___ and ___
Anti-P
P+ and P-
___, ___, or ___ may be found on RBCs, lymphocytes, granulocytes and monocytes
P1, P, or Pk
P can be found on platelets, ___ and ___
Epithelial cells and fibroblasts
P and Pk have also been found in plasma as ___ and as ___ in hydatid cyst fluid
glycosphingolipids; glycoproteins
P antigen: poorly expressed at birth and may take up to ___ years to be fully expressed
seven
P antigen deteriorates rapidly on storage – older RBCs used as control for typing reagents can lead to false ___ result
negative
P antigen has been identified in hydatid cyst fluid (___), ___ (common earth worm) and Ascaris suum
E. granulosus
Lumbricoides terrestris
P1-like antigen has been found on: (Give 3)
Plasma
Droppings of pigeon and turtle doves
Eggwhite of turtle doves
Blacks have a stronger expression of (P1) than whites
True
___ marker of apoptosis in germinal center B cells, Burkitt lymphoma, and lymphoblastic leukemia
Pk antigen
A receptor for Shiga toxins which cause Shigella dysentery and E. coli-associated hemolytic uremic syndrome (HUS) and also provides protection against HIV infection of peripheral blood mononuclear cells
Pk antigen
Autoanti-P
- PNH (Paroxysmal nocturnal hemoglobinuria)
OR
- PCH (paroxysmal cold hemoglobinuria)
PCH (paroxysmal cold hemoglobinuria)
Anti-P1: observed in individuals infected with ____; have also been found in patients with fascioliasis (bovine liver fluke disease) and in bird handlers
Echinococcus granulosus
___ originally called as anti- (“T” = tumor) was first described in the serum of Mrs. Jay, a p individual with adenocarcinoma of the stomach
Anti-PP1Pk
Produced by p individuals early in life without RBC sensitization and reacts with all RBCs except those of the p phenotype
Anti-PP1Pk
Anti-PP1Pk is associated with ___ in early pregnancy
spontaneous abortions
Anti-Pk is associated with ___ and autoimmune hemolytic anemia
biliary cirrhosis
P system antigens also serve as receptors for ___ – a cause of UTI
P-fimbriated uropathogenic E. coli
P is the receptor of human ___
parvovirus B19
ISBT 002
MNS
How many antigens have been included in the MNS system that makes it almost equal to Rh in size and complexity?
49
___ antigens is found on glycophorin ___ and they are antithetical antigens – easily destroyed by enzymes
MN
A
___ antigens is found on glycophorin ___ and they are antithetical antigens – less easily destroyed by enzymes
Ss
B
In MNS, the _____:
reacts best when acidified;
pH-dependent (reacts best at pH 6.5);
shows DOSAGE effect
Anti-M
In MNS, the _____ is seen in renal patient, who are dialyzed on equipment sterilized with formaldehyde
Anti-N
In MNS, the Anti -___
___ = universal; found on black people
U
En(a-) phenotype: M-N-
—> Confers resistance to ___ merozoite
Plasmodium falciparum
_____ phenotype:
null phenotype;
typed as M-N-S-s-U-En(a-)Wr(a-b-), but has a normal hematologic picture
Mk
In MNSS, the ___ may serve as the receptor by which certain pyelonephritogenic strains of E. coli gain entry to the urinary tract
Glycophorin A
The malaria parasite ___ appears to use alternative receptors, including GPA and GPB
Plasmodium falciparum
ISBT number of “I” which is also known as individuality”
027
At birth, infant red cells are rich in (i or I) and
(i or I) is almost undetectable
rich in i
undetectable in I
During the first ___ of life, the quantity of i slowly decreases as I increases until adult proportions are reached;
adult red cells are rich in I and have only trace amount of i antigen
18 months
There is NO true I- or i- phenotype
true
I and i are NO antithetical antigens
True
In ISBT 027: I, ___ is common antibody that can be benign or pathologic
Anti-I
Anti-I demonstrates strong reactions with (adult/cord) cells and weak reactions with (adult/cord) cells
adult
cord
Anti-I is not associated with ___ because the antigen is poorly expressed on infant red cells
HDN
Benign Anti-I
OR
Pathologic Anti-I / Anutoanti-I
is found in the serum of normal healthy adults; not associated with an in vivo red cell destruction
Benign Anti-I
Benign Anti-I
OR
Pathologic Anti-I / Anutoanti-I
patients with Mycoplasma pneumoniae often develop strong cold agglutinin with I specificity as a cross-reactive response to Mycoplasma antigen
Pathologic Anti-I / Anutoanti-I
Pathologic Anti-I / Anutoanti-I:
___ organism from a patient with cold autoimmune hemolytic anemia has been reported to absorb anti-I and stimulate its production in rabbits
Listeria monocytogenes
Pathologic Anti-I / Auto anti-I:
Associated with ___ disease
cold agglutinin
(Anti-i / Anti-I) is associated with infectious mononucleosis, alcoholic cirrhosis, myeloid leukemia and reticuloses
Anti-i
Anti-I^T:
T = transition
Naturally occurring antibody among Melanesians, coastal residents of Papua New Guinea, Yayoma and Venezuela
Have been found in patients with ___, with special association with Hodgkin’s lymphoma
warm autoimmune hemolytic anemia (WAIHA)
Chronic dyserythropoiesis anemia type II or hereditary erythroblastic multinuclearity with a positive acidified serum test <HEMPAS> is associated with much greater
---> (I or i) activity</HEMPAS>
i activity
In Asians, the “i” adult phenotype has been associated with ___
congenital cataracts
ISBT 008
Duffy
Named for Mr. Duffy, a multiply transfused hemophiliac who in 1950 was found to have the first described example of ___
anti-Fya
___ is important for invasion of Plasmodium vivax and Plasmodium knowlesi
Fy6
Anti-Fya and anti-Fyb have been associated with ___ & ___
acute & delayed HTRs
Unlike Fya and Fyb, the ___ antigen is not destroyed by enzymes
Like (ans in the first blank), ___ is not also destroyed by enzymes
Fy3
Fy5
In Duffy, the Fy(___) is commonly found in black population
(a-b-)
ISBT 009
KIDD
Found on Mrs. Kidd whose infant has ___
HDN
___ antibodies have a notorious reputation in the blood bank (What ISBT?)
Kidd
Kidd is the most common cause of ___
delayed hemolytic transfusion reaction (DHTR)
Drug-induced autoantibody is associated with Kidd blood group system on patient receiving ___ and another was CHLORPROPAMIDE-dependent
ALDOMET/METHYLDOPA
KIDD blood group system
Jk(___)
null phenotype;
most abundant among Polynesian, and is identified in Filipinos, Indonesian, Chinese, and Japanese
(a-b-)
Jk(a-b-) also resists lysis to ___
2M urea
With Jk(a+) or Jk(b+) RBCs, lysis in 2M urea occurs within how many minute/s?
With Jk(a-b-) cells, lysis is delayed by how many minute/s?
1 minute
30 minutes
ISBT 006
KELL
Excluding ABO, this ISBT (__) is rated second only to D in terms of immunogenicity
K
KELL consists of ___ high-prevalence & low-prevalence antigens;
36
___ was the first blood group system discovered after the introduction of antiglobulin testing
KELL
___ antigen can be detected on fetal RBCs as early as 10 weeks and is well developed at birth
K
Kell blood group antigens are found only on what blood cells?
RBCs
Kell antigen expression is dependent upon the presence of ___ protein
Xk
In Kell, the ___ Syndrome:
- absence of Xk results
- associated with chronic granulomatous disease (CGD)
McLeod
Depressed Kell antigens are seen on RBCs with the rare ___-negative phenotypes
Ge: -2, -3, 4 and Ge: -2, -3, -4
Gerbich