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3rd yr 2nd sem > ISBB - Diseases Associated with other BGS > Flashcards

ISBB - Diseases Associated with other BGS Flashcards

1
Q

ISBT 002: MNS

Anti-N

A

renal patient

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2
Q

ISBT 002: MNS

En(a-) phenotype: M-N-

A

Plasmodium falciparum merozoite

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3
Q

ISBT 003: P1PK

P antigen has been identified in ___, ___, and ___

A

hydatid cyst fluid (E. granulosus)
Lumbricoides terrestris (common earth worm)
Ascaris suum

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4
Q

ISBT 003: P1PK

Pk antigen is a marker of apoptosis in ___, ___, and ___

A

germinal center B cells
Burkitt lymphoma
lymphoblastic leukemia

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5
Q

ISBT 003: P1PK

Pk antigen is a receptor for Shiga toxins which cause ___ and ___

A

Shigella dysentery
E. coli-associated hemolytic uremic syndrome (HUS)

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6
Q

ISBT 003: P1PK

Pk antigen provides protection against ___ of peripheral blood mononuclear cells

A

HIV infection

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7
Q

ISBT 003: P1PK

Autoanti-P

A

PCH (paroxysmal cold hemoglobinuria)

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8
Q

ISBT 003: P1PK

Anti-P1 is observed in individuals infected with ___; have also been found in patients with ___ (bovine liver fluke disease) and in bird handlers

A

Echinoccocus granulosus
fascioliasis

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9
Q

ISBT 003: P1PK

Anti-PP1Pk is originally called as anti-
(“T” = tumor) was first described in the serum of Mrs. Jay, a p individual with ___ of the stomach

A

adenocarcinoma

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10
Q

ISBT 003: P1PK

Anti-PP1Pk is also associated with ___ in early pregnancy

A

spontaneous abortions

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11
Q

ISBT 003: P1PK

Anti-Pk is associated with ___ and a___

A

biliary cirrhosis
autoimmune hemolytic anemia

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12
Q

ISBT 003: P1PK

P system antigens also serve as receptors for ___ – a cause of UTI

A

P-fimbriated uropathogenic E. coli

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13
Q

ISBT 003: P1PK

P is the receptor of ___

A

human parvovirus B19

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14
Q

ISBT 005: LUTHERAN

Named from the donor Lutheran when an anti-Lu(a) was discovered in serum of a patient with ___ following transfusion

A

SLE / systemic lupus erythematosus

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15
Q

ISBT 005: LUTHERAN

Anti-Lub is implicated with shortened survival of transfused cells and posttransfusion ___

A

jaundice

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16
Q

ISBT 006: KELL

McLeod Syndrome:
~ absence of Xk results
~ associated with ___

A

chronic granulomatous disease (CGD)

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17
Q

ISBT 006: KELL

Patients with ___, in which the autoantibody is directed against a Kell antigen, may have depressed expression of that antigen

A

autoimmune hemolytic anemia

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18
Q

ISBT 006: KELL

Anti-K is associated with ___

A

severe HDN

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19
Q

ISBT 007: LEWIS

Lack of expression of Lewis antigens has been demonstrated on the RBCs of patients with ___, ___, and ___

A

cancer
alcoholic cirrhosis
viral and parasitic infections

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20
Q

ISBT 007: LEWIS

It also causes mild ___

A

HTR

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21
Q

ISBT 008: DUFFY

Fy6 is important for invasion of ___ and ___

A

Plasmodium vivax
Plasmodium knowlesi

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22
Q

ISBT 008: DUFFY

Anti-Fya and anti-Fyb have been associated with ___ & ___

A

acute HTRs
delayed HTRs

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23
Q

ISBT 008: DUFFY

Fy(a-b-)
~ Resist infection in vitro by the monkey malaria organism Plasmodium knowlesi and Plasmodium vivax
~ Has been linked to lower neutrophil counts, susceptibility to ___, ___, and reduced ___ following renal transplantation

A

infection
renal disease
graft survival

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24
Q

ISBT 009: KIDD

Found on Mrs. Kidd whose infant has ___

A

HDN

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25
Q

ISBT 009: KIDD

Most common cause of ___

A

delayed hemolytic transfusion reaction (DHTR)

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26
Q

ISBT 010: DIEGO

Associated with ___, ___, and southeast Asian ___

A

hereditary spherocytosis
acanthocytosis
ovalocytosis

27
Q

ISBT 010: DIEGO

Anti-Dia

Anti-Dia & Anti-Dib

Anti-Wra

Autoanti-Wrb

Anti-ELO

A

HDFN (Venezuelan baby)

HTRs and HDFN

severe HTRs

Warm Autoimmune Hemolytic Anemia

severe HDFN

28
Q

ISBT 011: CARTWRIGHT

~ Do not cause HDFN
~ Absent from RBCs of people with ___

A

PNH III

29
Q

ISBT 012: XG

___ is not implicated in HDFN or as a cause of HTRs

A

Anti-Xga

30
Q

ISBT 013: SCIANNA

~ Not cause of severe ___
~ Mild ___ (except for one severe case for antiRd for w/c the baby required exchange transfusion)

A

HTR
HDFN

31
Q

ISBT 014: DOMBROCK

Anti-Doa and Anti-Dib is not associated with ___, but reported to cause ___

A

HDN
delayed transfusion reactions / delayed HTRs

32
Q

ISBT 015: Colton

Anti-Coa

Anti-Cob

Anti-Co3

A

HTRs, HDFN

HTRs, mild HDFN

mild HTR, severe HDFN

33
Q

ISBT 016: Landsteiner-wiener

Autoanti-LW is common in serum from patients with ___

A

warm autoimmune hemolytic anemia

34
Q

ISBT 017: CHIDO/RODGERS

A

Clinically insignificant for transfusion

35
Q

ISBT 020: GERBICH

  • Leach Phenotype: ___
  • Rh Null Syndrome: ___
  • McLeod Phenotype: ___
A

+ elliptocytes
+ stomatocytes
+ acanthocytes

36
Q

ISBT 020: GERBICH

Ge Null Phenotype:
___

A

elliptocytic (mild anemia)

37
Q

ISBT 020: GERBICH

Anti-Ge3:
~ ___
~ ___ (late onset) associated w/ inhibition of erythroid cell growth and early onset of hemolysis

A

serious HDFN
severe anemia

38
Q

ISBT 021: CROMER

~ Do not cause ___
~ Anti-Cra and Anti-Tca causes ___

A

HDFN
HTRs

39
Q

ISBT 022: KNOPS

Clinically insignificant for ___and ___

A

transfusion
HDFN

40
Q

ISBT 023: INDIAN

In(a-b-): ___

Anti-Ina and Anti-Inb: ___

 Anti-Ina: decreased survival
 Anti-Inb: ___

A

Congenital dyserythropoietic anemia

+ DAT but no clinical HDFN

immediate HTR

41
Q

ISBT 024: OK

___ is a receptor essential for invasion by Plasmodium falciparum

A

Basigin

42
Q

ISBT 024: OK

~ Causes reduced survival of ___ RBCs injected into original antibody maker, suggesting clinical significance w/c is predicted by in vitro monocyte-monolayer assay

~ No reports of HDFN

A

Cr-labeled Ok(a+)

43
Q

ISBT 025: RAPH

Clinical significance in:

A

Transfusion

44
Q

ISBT 026: JOHN HAMILTON HAGEN

Clinically significant or Clinically insignificant

A

Clinically insignificant

45
Q

ISBT 027: I

Anti-I is a common antibody that can be benign or pathologic

Pathologic Anti-I or Autoanti-I:
~ Patients with ___ often develop strong cold agglutinin with I specificity as a cross-reactive response to Mycoplasma antigen

A

Mycoplasma pneumoniae

46
Q

ISBT 027: I

Pathologic Anti-I or Autoanti-I:

Listeria monocytogenes organism from a patient with ___ has been reported to absorb anti-I and stimulate its production in rabbits

A

cold autoimmune hemolytic anemia

47
Q

ISBT 027: I

Is associated with much greater i activity

A

Chronic dyserythropoiesis anemia type II

OR

Hereditary erythroblastic multinuclearity with a positive acidified serum test (HEMPAS)

48
Q

ISBT 027: I

Anti-I is a common antibody that can be benign or pathologic

___:
~ found in the serum of normal healthy adults
~ not associated with an in vivo red cell destruction

A

Benign Anti-I

49
Q

ISBT 027: I

In Asians, the i adult phenotype has been associated with ___

A

congenital cataracts

50
Q

ISBT 027: I

Pathologic Anti-I or Autoanti-I:

Associated with ___ disease

A

cold agglutinin

51
Q

ISBT 027: I

Anti-i is associated with ___, alcoholic cirrhosis, ___, and ___

A

infectious mononucleosis
myeloid leukemia
reticuloses

52
Q

ISBT 027: I

Anti-I^T
~ Have been found in patients with ___, with special association with ___

A

warm autoimmune hemolytic anemia (WAIHA)

Hodgkin’s lymphoma

53
Q

ISBT 029: GILL

~ No clinical ___
~ Causes ___

A

HDFN
HTR

54
Q

ISBT 030: RHAG

Anti-RHAG4: ___

A

severe HDFN

55
Q

ISBT 031: FORS

Human cells that express the FORS1 may have an increased susceptibility to ___ infection

A

E. coli

56
Q

ISBT 032: JR

~ Severe ___
~ ___

A

HDFN
HTR

57
Q

ISBT 033: LAN

~ Immediate ___
~ Not known to cause severe ___

A

HTR
HDFN

58
Q

ISBT 034: VEL

~ Severe immediate ___
~ Severe ___

A

HTRs
HDFN

59
Q

ISBT 035: CD59

___: is an acquired hemolytic anemia caused by a mutation in the GPI-linker gene

A

Paroxysmal Nocturnal Hemoglobinuria (PNH)

60
Q

ISBT 035: CD59

Other causes besides PNH:

A

Hemolysis
Strokes
Neuropathy

61
Q

ISBT 036: AUGUSTINE

~ Mild ___
~ Severe ___

A

HDFN
HTRs

62
Q

LUKE (LKE) ANTIGEN

Associated with ___ and metastasis in ___

A

Hodgkin’s lymphoma
renal carcinoma

63
Q

LUKE (LKE) ANTIGEN

Decreased expression of the LKE is seen in individuals with the Se gene with secretors having a 3- to 4-fold decreased risk of ___ infections

A

E. coli

3rd yr 2nd sem (4 decks)

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