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Gastrointestinal > Irritable Bowel Syndrome > Flashcards

Irritable Bowel Syndrome Flashcards

1
Q

Which of the following medications has withdrawal symptoms ( hyperhidrosis, chills, diarrhea, abdominal pain, anxiety, irritability, and yawning) ?

A. Chloride Channel Agonists

B. Serotonin Agonists

C. Mu Antagonists

D. Mu Agonists

A

C.

REMEMBER:

  1. Methylcatrexone (Relistor)
  2. Movantik ( Naloxegal)

The other side effects include:

  • Abdominal Pain
  • Hyperhidrosis
  • flatulence
  • Nausea
  • Diarrhea
  • Headache
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2
Q

What is the brand name of Tegoserod?

A. Lotronex

B. Viberzi

C. Zelnorm

D. Amitiza

A

C.

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3
Q

Which of the following medications do you need a negative pregnancy test?

A. Movantik ( Naloxegal)

B. Lubiprostone ( Amitiza)

C. Tegoserod ( Zelnorm)

D. Linaclotide ( Linzess)

A

B

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4
Q

What is the MOA of Eluxadoline ( Viberzi)? (select all that apply)

A. Locally activates the CIC-2 Chloride channel in large intestine

B. Delta receptor agonist

C. Mu and Kappa agonists

D. Delta receptor antagonist

E. Mu and kappa antagonist

A

C, D

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5
Q

Which of the following medications are Mu antagonists?

A. Amitiza (lubiprostone)

B. Relistor ( Methylnatrexone)

C. Naloxegal ( Movantik)

D. Zelnorm ( Tegoserod)

A

B, C

A is a chloride channel agonist

D is a serotonin Agonist

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6
Q

What are the counseling points of Amitiza ( lubiprostone)? (select all that apply)

A. Contraindicated in pediatric patients under 6 y/o age

B. Approximately 30% of patients experience a bowel movement within 30 minutes…advise patients to be within close proximity to the toilet.

C. Use effective contraception during treatment

D. Do not chew or break capsulres

A

C, D

Other things are to take with food and water to reduce the frequency and severity of nausea

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7
Q

Which of the following is the MOA of lubiprostone ( Amitiza)?

A. Locally activates the CIC-2 Chloride channel in large intestine

B. 5-HT4 receptor PARTIAL agonists, it stimulates the peristaltic reflex and intestinal secretion

C. Selective, peripherally acting, mu-opioid receptor antagonist

D. guanylate cyclase-C (GC-C) agonist that increases cGMP

A

A.

NOTE: Increases a chloride-rich intestinal fluid secretion w/o alterin sodium and potassium serum concnetration

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8
Q

What is the brand name of Methylnatrexone?

A. Naloxegal

B. Relistor

C. Amitiza

D. Zelnorm

A

B. Relistor

Naloxegal is movantik

Amitiza is lubiprostone

zelnorm is tegoserod

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9
Q

What are the counseling points of Naloxegal?

A. Approximately 30% of patients experience a bowel movement withing 30 min…advise them to be within close proximity to toilet

B. Take with food and water to reduce the frequency and severity of nausea

C. Use effective contraception during treatment

D. Do not break or chew capsules

A

A.

B,C, D are for chloride channel agonists ( Amitiza)

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10
Q

Which of the following medications has the following…

  1. Ischemic Colitis
  2. Mesenteric Ischemia
  3. Gangrenous Bowel
  4. Rectal Bleeding

A. Mu-Antagonists

B. Guanylate Cyclase Agonists ( cGMP Agonists)

C. Serotonin Antagonists

D. Serotonin Agonists

A

D

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11
Q

What is the indication of Amitiza? (Select all that apply)

A. Treatment of Chronic idiopathic constipation in adults

B. Treatment of IBS-C in women 18 y/o

C. Treatment of IBS-C in adults

D. Hepatic Encephalopathy

A

A, B

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12
Q

Which of the following medications is contraindicated in pediatric patients under 6 y/o?

A. Lubiprostone (Amitiza)

B. Methylnatrexone (Relistor)

C. Linaclotide ( Linzess)

D. Rifaximin ( Xifaxan)

A

C

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13
Q

Which of the following medication (s) is indicated for the treatment of opioid induced constipation in adult patients with chronic non-cancer pain?

A. Alosentron ( Lotronex)

B. Linaclotide ( Linzess)

C. Movantik ( Naloxegal)

D. Methylnatrexone (Relistor)

E. Both A and B

F. Both C and A

A

F

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14
Q

What is the MOA of Linaclotide ( Linzess)?

A. Locally activates the CIC-2 Chloride channel in large intestine

B. 5-HT4 receptor PARTIAL agonists, it stimulates the peristaltic reflex and intestinal secretion

C. Selective, peripherally acting, mu-opioid receptor antagonist

D. guanylate cyclase-C (GC-C) agonist that increases cGMP

A

D

Increases cGMP will stimulate chloride and bicarbonate secretion in the intestinal lumen by activating the CTFR channel which increases intestinal fluid and increased GI Transit time

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15
Q

Which of the following is the MOA of Mu Antagonists?

A. Locally activates the CIC-2 Chloride channel in large intestine

B. 5-HT4 receptor PARTIAL agonists, it stimulates the peristaltic reflex and intestinal secretion

C. Selective, peripherally acting, mu-opioid receptor antagonist

D. guanylate cyclase-C (GC-C) agonist that increases cGMP

A

C

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16
Q

Which of the following statments regarding Rifaximin is true?

A. MOA is a bacterial protein syntheisis inhibitor

B. May cause increased ALT

C. Indicated for travel’s diarrhea and hepatic encephalopathy

D. All of the above

A

D

17
Q

Which of the following medications causes spasms of the sphincter of Oddi leading to pancreatitis?

A. Eluxadoline ( Viberzi)

B. Linaclotide ( Linzess)

C. Lubiprostone ( Amitiza)

D. Rifaximin ( Xifaxan)

A

A

18
Q

What is the MOA of Alosentron ( Lotronex)?

A. Locally activates the CIC-2 Chloride channel in large intestine

B. 5-HT4 receptor PARTIAL agonists, it stimulates the peristaltic reflex and intestinal secretion

C. Selective, peripherally acting, mu-opioid receptor antagonist

D. 5HT-3 antagonist…greatly reduces GI motility

A

D

19
Q

Which of the following medications is indicated for the treatment of opioid induced constipation in patients with advanced illness who are receiving palliative care?

A. Alosentron ( Lotronex)

B. Linaclotide ( Linzess)

C. Movantik ( Naloxegal)

D. Methylnatrexone (Relistor)

E. Both A and B

F. Both C and A

A

D.

20
Q

Which of the following medications can cause ischemic colitis and serious consitpation?

A. Rifaximin ( Xifaxan

B. Eluxadoline ( Viberzi)

C. Alosentron ( Lotronex)

D. Linaclotide ( Linzess)

A

C

21
Q

What is the MOA of Zelnorm ( Tegoserod)?

A. Locally activates the CIC-2 Chloride channel in large intestine

B. 5-HT4 receptor PARTIAL agonists, it stimulates the peristaltic reflex and intestinal secretion

C. Selective, peripherally acting, mu-opioid receptor antagonist

D. guanylate cyclase-C (GC-C) agonist that increases cGMP

A

B

22
Q

Which of the following statements are true regarding the indication of Tegoserod? (select all that apply)

A. It is a serotonin Agonists

B. It is for short-term treatment of MEN with IBS-C

C. It is for short-term treatment of WOMEN with IBS-C

D. It is for patients less than 65 y/o with chronic idiopathic constipation

E. Diarrhea can be a pharmacologic response

A

A,C,E

Gastrointestinal (3 decks)

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