Inflammatory Bowel Diseases Flashcards
What is the brand name of sulfasalazine?
A. Azulfidine
B. Asacol
C. Colazal
D. Dipentume
A. Azulfidine
b is the brand name for mesalamine
c is the brand name for balsalazide
d is the brand name for olsalazine
What is the MOA of Sulfasalazine (Azulfidine)?
A. Selectively inhibits T-Cells Formation
B. Inhibition of lipoxygenase
C. Inhibits Dihydrofolate reductase which inhibits DNA synthesis
D. Binds to proteins called immunophilins
B. inhibits lipoxygenase
Which of the following medications causes orange-yellow color in alkaline urine?
A. Olsalazine ( Dipentum)
B. Balsalazide ( colazal)
C. sulfasalazine ( Azulfidine)
D. Mercaptopurine ( Purinethol)
C. Sulfasalazine
From the PowerPoint:
Other Side Effects:
GI:
- Nausea/ Vomiting
- Dyspepsia
- Anorexia
Hematological:
- Hemolysis
- Folate Deficiency
Other:
- Headache
- Reversible Male Infertility
- Orange-Yellow Color in Alkaline Urine
Which of the following is a side effect of olsalazine ( Dipentum)?
A. Headaches
B. Dyspepsia
C. Nausea/ Vomiting
D. Diarrhea
D. Diarrhea
This drug occurs as a result of a secretagogue property
Which of the following are side effects of Balsalazide ( Colazal)?
( Select all that apply)
A. Headache
B. Dyspepsia
C. Nausea/ Vomiting
D. Diarrhea
A, B, C
Which of the following is the brand name of Olsalazine?
A. Colazal
B. Dipentum
C. Purinethol
D. Imuran
B.
Which of the following is the brand name of Balsalazide?
A. Imuran
B. Dipentum
C. Colazal
D. Tacrolimus
C. Colazal
Which of the following medications has this mechanism of action? (Select all that apply)
- Immunosuppresant: Selectively Inhibits T-Cell Formation
- Cytotoxicity: Purine antagonist which will inhibit DNA and RNA synthesis
A. Mercaptopurine
B.Tacrolimus
C. Azathioprine
D. Cyclosporine
A,C
Which of the following medications inhibits dihydrofolate reductase which inhibits DNA synthesis and promotes apoptosis of activated T-Cells?
A. Azathioprine ( Imuran)
B. Mercaptopurine (Purinethol)
C. Methotrexate ( Amethopterin, MTX, Mexate)
D. Cyclosporin ( Sandimmune)
C
Which of the following medications has the black box warning of
- Increased risk of development of lymphoma and other malignancies, particularly of the skin, due to immunosuppresion
- Increased Susceptibility to bacterial, viral, fungal, and protozoan infections, including opportunistic infection
A. Olsalamine
B. Methotrexate
C. Cyclosporin A
D. Azathioprine
C.
What is the brand name of infliximab?
A. Cimzia
B. Remicade
C. Simponi
D. Humira
B.
What is the brand name of certolizumab?
A. Cimizia
B. Simponi
C. Remicade
D. Humira
A.
What is the brand name of adalimumab?
A. Simponi
B. Cimzia
C. Remicade
D. Humira
D.
What is the brand name of golmumab?
A. Cimzia
B. Simponi
C. Remicade
D. Humira
B.
What is the MOA of TNF-alpha blockers?
Monoclonal antibody that will bind to TNF-alpha and prevent it from binding to its receptors
