iron regulation

Question 1

HFE

Answer 1

• regulates circulating iron uptake by regulating interaction of TFR1/2 with transferrin
• responsible for most iron overload (hemochromatosis)

Question 2

HJV

Answer 2

juvenile hemochromatosis, rare but severe

Question 3

TFR2

Answer 3

involved in uptake of transferrin-bound iron into cells by endocytosis, minor compared to TFR1

Question 4

hepcidin/HAMP

Answer 4

key regulator of entry of iron into circulation

Question 5

TFR1

Answer 5

required for iron import from transferrin into cells by endocytosis

Question 6

ferroportin

Answer 6

transmembrane protein that transports iron outside of cell

-inhibited by hepcidin, causing iron retention in enterocyte