hormones that regulate feeding behavior

Question 1

ghrelin

Answer 1

• secreted by gastric endocrine cells
• binds to growth hormone secretagogue receptor
• stimulates release of NPY in hypothalamus
  
  • increase appetite, motility, gastric acids

Question 2

insulin

Answer 2

• binds to POMC and NPY systems in hypothalamus
• inhibits NPY pathway
• stimulates POMC pathway
  
  • decresases appetite
  • increases metabolism

Question 3

PYY

Answer 3

• released by EEC (L cells) of ileum and colon
• binds Y2 receptors of hypothalamus
• inhibits NPY neurons
• releases inhibition of POMC neurons
• potential appetite suppressor

Question 4

Leptin

Answer 4

• secreted by adipose tissue and endocrine cells in stomach
• binds receptors in hypothalamus
  
  • inhibits NPY
  • stimulates POMC
• decrease appetite
• increase metabolism
• decrease ghrelin release