Iron in Health and Disease Flashcards
Major site of iron storage
liver
vast majority of iron is present in
hemoglobins in RBCs
DMT1
divalent metal transporter that transports Fe2+ into enterocytes
Ferritin
stores protein within cells
Hephaestin
oxidzes Fe2+ to Fe3+ when leaving the enterocyte to prep it for for binding to transferrin
TFR
receptors that take in Fe2+ from transferrin
HFE (High Fe)
interacts with TFN receptors (TFN1)
____ levels in serum usually reflect body Fe stores
Ferritin levels
An important exporter cell
enterocyte
TFR
transferrin receptors –all cells have this for import
Hepcidin is produced almost exclusively by _____
hepatocytes
Master hormone regulating iron export and role
Hepcidin: acts as a brake by binding and degrading ferroportin. Blocks cellular Fe export
Factors that regulate serum hepcidin levels and order of priority
inflamation/infection > anemia/hypoxia > iron levels
How does intracellular iron levels regulate serum hepcidin?
- feedback mechanism
- high intracellular Fe increases hepcidin production
How does anemia/hypoxia affect hepcidin levels?
Low hemoglobin decreases hepcidin production. Need to maintain oxygen carrying capacity
How does inflammation/infection affect hepcidin levels?
Increase hepcidin production and decreases serum iron levels
want to deprive infection from iron–evolution
True or false: The factors regulating serum hepcidin levels can coexist and do not exert equal control
True.
Decreased hepcidin levels increase _____
ferroportin levels
Iron deficiency anemia results in (increased/decreased) hepcidin levels
decreased
condition response to iron supplementation
In anemia of chronic inflammation, what would you expect these levels from lab to be?
- Hgb
- Hct
- serum Fe
- Fe binding capacity
- serum ferritin
- RBC size
- low Hgb
- low Hct
- low serum Fe
- low Fe serum binding capacity
- normal serum Ferritin
- normal or small sized RBCs
In anemia of chronic inflammation, what happens to hepcidin levels?
Is Fe supplementation effective?
inflammation overrides anemia stimulus
-you get increased hepcidin to inhibit ferroportin and thus export of Fe from enterocytes and macrophages.
- in anemia, you would want decreased hepcidin to get more Fe out to RBCs.
- supplement not effective-primary problem is Fe incorporation into RBCs
In anemia with ineffective erythropoeisis, what would you expect the levels to be of lab results?
- Hgb
- Hct
- Serum Fe
- Fe binding capacity
- serum ferritin
- RBCs
- low Hgb
- low Hct
- high, highly saturated (transfusions increases Fe load and RBCs cant take up as much)
- high serum ferritin
- small, microcytosis
In ineffective erythropoeisis, what happens to hepcidin?
Anemia overrides Iron levels. So you will get decreased hepcidin and increased ferroportin. Gut, macrophages, liver increase Fe export to bone marrow. Transfusions add Fe. = Fe OVERLOAD!
What is used to assess iron binding capacity?
transferrin
