IP5 Exam I

Question 1

Placental imm v. Colostrum

Answer 1

Eq, Ru, Su: ⛔️ v. 100%
Dog+cat: 10 v. 90%
Hu, mouse: 90 v. 10

Question 2

Colostrum v. Milk

Answer 2

Apes: IgA v. IgA
Monogastric: IgG v. IgA
Ru: IgG v. IgG

Question 3

Autologous/autograft

Answer 3

Self transplant ➡️⛔️reject

Question 4

Syngenic/isograft

Answer 4

Genetically identical donor, same spp

Question 5

Allogenic/allograft

Answer 5

Dissim genes, same spp

Question 6

Xenogenic/xenograft

Answer 6

Diff spp ➡️reject

Question 7

Direct alloAg recognition

Answer 7

Host T-cells (CD8+4) senses

DONOR APC w/MHC

Question 8

Indirect alloAg recog

Answer 8

HOST APC senses Donor tissue➡️❇️CD4 chronic rejection

Minor Histocompatability Ag

Question 9

Adoptive cell therapy

Answer 9

Ex vivo il-2:❇️CTL+NK cells ➡️⛔️tumor

Question 10

il-12

Answer 10

❇️Th1➡️IFN-y :✳️M➰ + B-cells Ab

Question 11

il-6 + TGF-ß

Answer 11

❇️Th17: il-17 prod

il-23 maintain Th17

Question 12

il-17 + il-1

Answer 12

❇️neuts + NK cell: IFN-y prod

➡️❇️M➰

Question 13

Type 1 IFN

Answer 13

IFN-a: WBC
IFN-ß: fibroblast + epi

✳️➰-viral state: ⬆️MHC I + il-12R

Question 14

Helminth

Answer 14

B-cell: ❇️Th2➡️

il-4➡️❇️IgE:✳️mast cells gran rel
il-5➡️recruit eosinophils
il-13➡️❇️goblet cell hyperplasia: mucous