Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Immuno > Exam I > Flashcards

Exam I Flashcards

0
Q

Microbe ➡️ dis

Flora in wrong location

A

Pathogen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
1
Q

Normal flora of microbes ⛔️opportunistic microbe colonization

A

Commensal spp

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Must live in host cell

Ex:listeria

A

Obligate organism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

CD4+

A

MØ+Ag:✳️HelpT-Cell➡️✳️M➰ killfn

IgM B-cell: ✳️H T-cell➡️✳️IgM⏩E/G

MHC II

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

CD8+

A

Cytotoxic T-Cell

MHC I

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

CD16

A

B-Cell ➡️plasma cell: Ab

NK Cells (Innate)⛔️req APC➡️⛔️viral

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Cardinal ft of AI

A

SHMENDS

Specificity
Contr& Homeostasis
Memory
Clonal Expansion
Nonrxn to SELF
Diversity
Specialization
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

CD25+

A

Regulatory T-Cell➡️⛔️autoimm&chaos

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

All T-Cells have this signal portion of R

W/ A&B chain

A

CD3+

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

CCR7

A

Naïve T cells chemokine R ➡️LN parafollicular cortex

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

CXCR5

A

Naïve B-cell chemokine R ➡️LN follicle

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

AMPs

A

Agg protiens on surface ➡️pore form

Defensins: ✳️inflam
Cathelicidins: neutralize LPS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

C-reactive proteins (CRP)

A

Opsonize & ✳️C’ pathway

MØ: rel IL-6➡️✳️liver: CRP secr➡️ binds Phosphocholine on dying cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

C’ Pathway

A

IgM complex/MB-Lectin/alt C3 path
➡️✳️C3 enz

C3a/C5a: chemokine➡️✳️inflam
C3b: opsonize
C5b: ✳️MAC pore ➡️lysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

PAMPs

A

Recog by PRR➡️✳️I.I.

DAMPs (recog. damage from necrotic cells)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

TLR (1+2) & (2+6)

A

Surface Lipopeptides

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

TLR 2

A

Surface bact peptidoglycans

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

TLR4

A

Surface LPS

18
Q

TLR5

A

Bact flagella

19
Q

TLR3

A

Endosome: dsRNA

20
Q

TLR 7

TLR 8

A

Endo: ssRNA

21
Q

TLR 9

A

CpG DNA

22
Q

TLR fn

A

Prime: ✳️MyD88
or TLR 3&4➡️TRIF➡️

  1. NF-kB(TF)➡️✳️syn gene➡️✳️AI & inflam
  2. IRF(TF)➡️✳️syn IFN type 1➡️✳️➰-viral state
23
Q

Phagocytes: 3 receptors

A

7-trans mem R➡️✳️cell migration
TLR&Mannose-R➡️opsonize + prod cytokines & ROIs➡️✳️ROS & NO ➡⚡️KILL microbes

&tissue remodeling

24
Q

B-1 cells

Innate-like lymphocytes

A

“Natural Ab” in IP cavity & spleen

ALL IgM ⛔️class switch
ID CHO& Lipids ➡️opsonize
✳️C' pathway (classic)

⛔️MHC & ⛔️memory

25
Q

➰:D T-cells

Innate-like lymphocytes

A

Waves of same R cells➡️sp location➡️ prod cytokines

W/ diff MHC recog
⛔️memory

26
Q

NK T-Cells

Innate-like lymphocytes

A

ID LIPIDS➡️prod cytokines

⛔️memory

27
Q

NK cells

A

ID stress/infx cells➡️⚡️direct KILL

28
Q

MHC I

A

On ALL cells➡️✳️CD8 CTL & NK Cells

29
Q

MHC II

A

On APC➡️✳️CD4 helper T-cells

30
Q

MØ + Ag

A

Secr IL-12➡️✳️NK Cells:secr IFN-➰
➡️✳️MØ kill fn & ⬆️both MHC exp

I.I. +A.I: IFN-➰ ⏩amplify✳️T-cell resp

31
Q

MØ cytokine: IL-1ß

A

✳️vasc endothelium/lympho➡️✳️fever & IL-6 prod

➡️✳️fever& acute protein prod &Ab prod

32
Q

MØ cytokine: IL-12

A

✳️NK Cells & ❇️CD4➡️H1 T-cell

33
Q

MØ cytokine: TNF-a

A

⬆️vasc perm: ⬆️IgG + C’ + fl drain

➡️fever& mobile metabolites

34
Q

MØ cytokine: CXCLB (IL-8)

A

Recruit: (prime) neutrophil+ basophil + T-cell➡️infx site

35
Q

Recruitment to infx site

A
  1. MØ+ Ag: rel TNF+IL-1✳️⬆️E+P Selectins on endothelium
  2. Bind Selectin➡️Rolling
  3. ⏫integrin(CAMs) aff➡️⛔️leukocyte
    ➡️crawl& follow chemokine gradient
36
Q

IFN-a + ß

Type 1

A

Rel by viral infx cell➡️✳️ uninf neighbor➡️❇️➰-viral state

⛔️viral syn & rep &✳️vRNA degrad

37
Q

Naïve T-Cells req (2) signals

A
  1. MHC-Ag: TCR

2. B7:CD28

38
Q

B2-cell + sp conform Ag

A

✳️endocytosis➡️peptide on MHC ➡️✳️effector TCR:❇️B-cell ➡️Plasma cell➡️Ab prod

39
Q

H2 MHC

A

Class 1: KDL
Class 2: I- A & E

Allele a, b, c…

Mouse

40
Q

HLA MHC

A

Class 1: ABC (27 alleles)

Class 2: DP DQ DR (4 alleles)

41
Q

MHC I

A

a + ß2-M

ALL cells
intracellular Ag➡️proteosome➡️TAP:ER➡️surface:✳️CD8 CTL

DC X-Presentation

42
Q

MHC II

A

a+ß

APC cells

Extracellular protein➡️endosome
Invariant chain⛔️MHC II in ER⏩
DM removes CLIP
Ag+ MHC II➡️surface:✳️CD4

Immuno (5 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions