Ion channel + Vasoactive Peptide Flashcards
what are ion channels
integral membrane proteins that allow ions to flow from different compartments
what is the function of ion channels
How is voltage-gated channel controlled and example of voltage-gated channel
Name 2 drugs that act on voltage-gated channel
cocaine
lidocaine
what channel is the Gaba receptor
and how is it controlled
Name 2 drugs that act on Gaba receptor
Nicotinic Acetylcholine receptor is what type of gated channel
how is it controlled
Name the antagonist and agonist of nicotinic acetylcholine receptor
Explain ion channel mechanism of action potential
Name a disease that is associated with ion channel function I
cystic fibrosis (deletion of phenylalanine at position 508)
Name a disease that is associated with ion channel function II
Long QT syndrome (mutation in cardiac potassium channel, loss in function)
What is the MOA of angiotensins
what is the renin -angiotensin system
what is the effect of angiotensin on cardiovascular system
increase blood pressure
what is the effect of angiotensin on adrenal gland
what is the effect of angiotensin on kidney
increase sodium and water reabsorption
what is the effect of angiotensin on CNS
what are the clinical use of angiotensins
Name 3 types of ATII antagonist
-name the drugs under each type
what is ACE inhibitor
name 2 example of ACE inhibitor
-prils
enalapril
captopril
what is the therapeutic use of ACE inhibitor
What is sartans, e.g losartan,valsartan
AT1 antagonist
when do you use sartans
what is renin inhibitor
aliskiren
what is a vasopressin
what is the MOA of vasopressin
name 3 examples of vasopressin receptor agonist
vasopressin
selepressin
desmopressin
what is the clinical use of desmopressin
ADH sensitive diabetes insipidus,
what is conivaptan
vasopressin antagonist, non selective
when do you use conivaptan
SIADH
what is tolvaptan
vasopressin antagonist, 30 fold
tolvaptan has more affinity to which receptor?
30 fold V2 > V1
