Invasive Fungal Infection Flashcards
Taxonomy of fungus
Is fungus a type of plant
Domain
Kingdom
Not a plant
Eukaryota
Fungi
Who gets serious fungal infection?7types of patients
Patients who have
1neutropenic.Chemotherapy -cancer haematology -Immunosuppressive
2Intensive therapy unit (ITU)
3Patients with central IV catheters
4HIV/AIDS- immunosuppression
5Solid organ transplant- anti rejection drug
6Long course corticosteroids- C11 Keto/OH
7Locally impaired IMS- poor blood circulation in part of body?
Where can we look for guiding evidence
European org for research and treatment of cancer/ mycoses study group EORTC/MSG
IDSA infectious diseases society of America
ESCMID euro society of clinical microbiology and infectious disease
Is building works a risk factor for fungal infection?
No for candida
Yes for aspergillus bc it is an environmental fungus
What are the main causative org
Candida spp -yeast
Aspergillus -mould -pulmonary infec
Cryptococcus neoformans- yeast- pulm, invasive CNS, HIV AIDS
Histoplasma capsulatum- envir. - pulm infec HIV AIDS
What’s candidaemia and where are the sources
Candida in blood
From GIT
Central venous catheters
How can candida and aspergillus be detected
By culture
Difficult to obtain blood cultures
Imaging and antibody detection (ab in respond to aspergillus)
2 types of aspergillus infections
1 aspergillosis
Invasive (disseminated) typically of lung origin
Allergic bronchipilmonary aspergillosis
2 aspergilloma (fungal ball) in cavity Saprophytic-live on dead matter
What are the complications of invasive pulmonary aspergillosis
Severe pneumonia
Disseminated to cns
Local invasion to heart etc
What’s the treatment for invasive pulmonary aspergillosis
Resection (surgical removal) of locally invasive lesions
What’s sepsis
Infection with systemic manifestations Circulation sys can't supply demands of body Leaky blood vessel reduced BP HYPOperfusion of organs Organ failure
Severe sepsis
Sepsis and sepsis induced organ dysfunction
Septic shock
Sepsis induced hypotension persisting despite adquent fliud
Clinical disagnostic indicator
Imaging
Resp leision/ cavity/ crescent air sign
CNS leision/ inflam maningi
Disseminate liver /spleen leisions
Indirect test for fungi infec
Galactomannan antigens in plasma NBL fliud
Beta D glucan in serum