Invasive Fungal Infection Flashcards

1
Q

Taxonomy of fungus
Is fungus a type of plant
Domain
Kingdom

A

Not a plant
Eukaryota
Fungi

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2
Q

Who gets serious fungal infection?7types of patients

A

Patients who have
1neutropenic.Chemotherapy -cancer haematology -Immunosuppressive
2Intensive therapy unit (ITU)
3Patients with central IV catheters
4HIV/AIDS- immunosuppression
5Solid organ transplant- anti rejection drug
6Long course corticosteroids- C11 Keto/OH
7Locally impaired IMS- poor blood circulation in part of body?

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3
Q

Where can we look for guiding evidence

A

European org for research and treatment of cancer/ mycoses study group EORTC/MSG
IDSA infectious diseases society of America
ESCMID euro society of clinical microbiology and infectious disease

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4
Q

Is building works a risk factor for fungal infection?

A

No for candida

Yes for aspergillus bc it is an environmental fungus

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5
Q

What are the main causative org

A

Candida spp -yeast
Aspergillus -mould -pulmonary infec
Cryptococcus neoformans- yeast- pulm, invasive CNS, HIV AIDS
Histoplasma capsulatum- envir. - pulm infec HIV AIDS

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6
Q

What’s candidaemia and where are the sources

A

Candida in blood
From GIT
Central venous catheters

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7
Q

How can candida and aspergillus be detected

A

By culture
Difficult to obtain blood cultures
Imaging and antibody detection (ab in respond to aspergillus)

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8
Q

2 types of aspergillus infections

A

1 aspergillosis
Invasive (disseminated) typically of lung origin
Allergic bronchipilmonary aspergillosis

2 aspergilloma (fungal ball) in cavity
Saprophytic-live on dead matter
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9
Q

What are the complications of invasive pulmonary aspergillosis

A

Severe pneumonia
Disseminated to cns
Local invasion to heart etc

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10
Q

What’s the treatment for invasive pulmonary aspergillosis

A

Resection (surgical removal) of locally invasive lesions

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11
Q

What’s sepsis

A
Infection with systemic manifestations 
Circulation sys can't supply demands of body 
Leaky blood vessel reduced BP
HYPOperfusion of organs 
Organ failure
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12
Q

Severe sepsis

A

Sepsis and sepsis induced organ dysfunction

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13
Q

Septic shock

A

Sepsis induced hypotension persisting despite adquent fliud

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14
Q

Clinical disagnostic indicator

A

Imaging
Resp leision/ cavity/ crescent air sign
CNS leision/ inflam maningi
Disseminate liver /spleen leisions

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15
Q

Indirect test for fungi infec

A

Galactomannan antigens in plasma NBL fliud

Beta D glucan in serum

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