Introduction to Personalized Medicine

Question 1

What is the main principe of personalized medicine?

Answer 1

Take individual variance into consideration of medical treatment

Question 2

What are the four “rights” of personalized medicine?

Answer 2

• Right patient
• Right drug
• Right time
• Right dose

Question 3

What is the goal of personalized medicine?

Answer 3

Provide the best therapeutic outcome

Question 4

What are the benefits of personalized medicine?

Answer 4

• More accurate diagnosis
• Optimal treatment option
• Increase safety
• Reduce adverse drug reactions
• Faster to a cure
• Increase efficacy of healthcare system
• Reduce ineffective therapies

Question 5

What are the foundations of personalized medicine?

Answer 5

• More accurate and personalized diagnostic methods
• Patient screening (based on biomarkers)
• The “omics”
• Biomarker identification
• Systems biology

Question 6

What are the “omics”?

Answer 6

These techniques help HCPs stratify patients into pharmaceutically and medically relevant groups

• Pharmacogenomics and pharmacogenetics
• Proteomics
• Transcriptomics
• Metabolomics
• Bioinformatics

Question 7

What are the most common “omics” used to stratify patients?

Answer 7

Pharmacogenomics and Transcriptomics are the cheapest methods, and therefore are the most widely used

Question 8

Review slide 17 for differences between conventional and personalized medicine

Question 9

What are some challenges associated with personalized medicine?

Answer 9

• Patient engagement
• Patient privacy
• Evidence collection
• Data ownership and management
• Cost