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HOAD BLOCK 1 > Introduction To IMMUNE System > Flashcards

Introduction To IMMUNE System Flashcards

1
Q

What are the two types of immune cells ?

A

Primary and secondary

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2
Q

Which is the most effective barrier of diseases?

A

Mucous memberane

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3
Q

What are the Antigen markers of stem cells ?

A

CD34
CD90

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4
Q

What is myelopoesis ?

A

Production of myeloid elements
Regulated by growth factors
(IL-3& SCF)

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5
Q

What are the circulating myeloid cells ?

A

Mono
Eosino
Baso
Neutrophils (most abundant)

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6
Q

What are the resident myeloid cells ?

A

Macro
Mast
Dendritic

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7
Q

What are the Antigen markers of B-CELL ?

A

CD19,20,21

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8
Q

CD MARKER OF NK CELLS?

A

CD16&56

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9
Q

What are the two selection of thymus ?

A

Positive - does it communicate with MHC

Negative - does it bind too strongly wotgh self peptides

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10
Q

What is the most abundant class of B CELL ?

A

B2 (BONE MARROW)

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11
Q

What are the 3 types of secondary lymphoid organs ?

A

Lymph node
Spleen
Malt

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12
Q

What is the site of interaction between T CELLS and Dendritic cells with free Antigen from tissue infection ?

A

Lymph nodes

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13
Q

What does lymph node generate ?

A

Plasma cells
Memory B cells
T CELLS and memory T cells

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14
Q

What is the function of peyers patch ?

A

Passes Antigen to lymphoid follicle by microfold cells

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15
Q

What forms IgA and other antibodies in Peyers patch ?

A

Antigen responce in Peyers patch and draining lymph node

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16
Q

What is lymphodema.?

A

Failure to clear lymph

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17
Q

What are the two types of tissue macrophages ?

A

In featus (self renewal)
After birth

18
Q

What innate immune cell respond to Helminthis and allergy ?

A

Mast cells

19
Q

Where does Dendritic cell mature ?

A

As they move on from peripheries to lymph node

20
Q

What is the main type of Pattern recognition receptor (PRR)?

A

TOLL LIKE RECEPTOR (TLR)

21
Q

What are the products of TLR stimulation ?

A

Increased cytokine prodc and transcription

Cytokine signalling

Recruitment of immune cells from circulation

22
Q

What are the products of resident macrophages stimulation ?

A

Release of vasoactive molecules

Stimulation of endothelial cells and leucocyte

23
Q

How does neutrophil leave blood during NO INFECTION?

A

BINDS TO SLIG AND FLOWS OUT

24
Q

How does Neutrophil move in infected tissue ?

A

Cytokine from macrophages makes endothelial cells sticker

ENDOTHELIAL CELLS PRODUCE E-SELECTIN

SLIG BINDS TO E- SELECTIN

Neutrophil ROLLS

25
Q

How does neutrophil move in a tissue receiving signal from infected tissue ?

A

Complement fragmets released from infected tissue causes neutrophils to produce INTEGRINS

INTEGRINS have CD18 causes to bind with ICAM and stops Neutrophil

26
Q

What is Diapedesis ?

A

Platelet Endothelial cell adhesion molecules (PECAM)

Causes neutrophils to squece through endothelial spaces

27
Q

What is chemotaxix ?

A

Attracting molecules such as C5a and FMET causes neutrophil to to move toward the infected site

28
Q

What are the features of inflammation ?

A

Rubour
Tumour
Calor (warmth)
Dolor (pain)
Loss of function

29
Q

What are the function of opsonins ?

A

Enhances Phagocytosis
(C3b) complement opsonins
(IgG) antibody opsonins
CRP
MBL

30
Q

What is the end product of ROS which is in beach ?

A

Hypochlorite (HCLO-)

31
Q

What is the other name of Human MHC ?

A

Human leukocyte Antigen
(HLA)

32
Q

Function of MHC class 1 ?

A

Expressed on cell surface
Antigen to CD8 (cyt t cell)

33
Q

MHC CLASS 2 Function ?

A

Present on Antigen Presenting cells (Dendritic cells)

Antigen to CD4 (T-help)

34
Q

Hoe do b cell become plamsa cells and memory cells ?

A

After contact with Antigen and receiving help from T help cell

35
Q

Immunoglobulin that secrete antibody on mucous memberane and can be a dimer or monomer

A

IgA

36
Q

Only antibody to cross placenta

A

IgG

37
Q

1st responding immunoglobin ?

A

IgM

38
Q

Immunoglobulin that’s a receptor of B CELL ?

A

IgD

39
Q

Immunoglobulin that binds to mast cell and basophils that also reacts to allergy and worm infections?

A

IgE

40
Q

How is NK cells activated and how does it kill?

A

Activated by IFN-1 AND PRODUCE IFN-2 taht stimulates Phagocytosis.

41
Q

What produces the don’t kill receptor for NK CELLS ?

A

MHC CLASS 1—> KIR
ABSENCE OF CLASS 1 —-> KAR

42
Q

What is Fas ligands (FasL) ?

A

TYPE OF SUICIDE OF NK CELLS WHICH ACTIVATES SELF DESTRUCTION.

HOAD BLOCK 1 (3 decks)

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