Introduction To IMMUNE System Flashcards
What are the two types of immune cells ?
Primary and secondary
Which is the most effective barrier of diseases?
Mucous memberane
What are the Antigen markers of stem cells ?
CD34
CD90
What is myelopoesis ?
Production of myeloid elements
Regulated by growth factors
(IL-3& SCF)
What are the circulating myeloid cells ?
Mono
Eosino
Baso
Neutrophils (most abundant)
What are the resident myeloid cells ?
Macro
Mast
Dendritic
What are the Antigen markers of B-CELL ?
CD19,20,21
CD MARKER OF NK CELLS?
CD16&56
What are the two selection of thymus ?
Positive - does it communicate with MHC
Negative - does it bind too strongly wotgh self peptides
What is the most abundant class of B CELL ?
B2 (BONE MARROW)
What are the 3 types of secondary lymphoid organs ?
Lymph node
Spleen
Malt
What is the site of interaction between T CELLS and Dendritic cells with free Antigen from tissue infection ?
Lymph nodes
What does lymph node generate ?
Plasma cells
Memory B cells
T CELLS and memory T cells
What is the function of peyers patch ?
Passes Antigen to lymphoid follicle by microfold cells
What forms IgA and other antibodies in Peyers patch ?
Antigen responce in Peyers patch and draining lymph node
What is lymphodema.?
Failure to clear lymph
What are the two types of tissue macrophages ?
In featus (self renewal)
After birth
What innate immune cell respond to Helminthis and allergy ?
Mast cells
Where does Dendritic cell mature ?
As they move on from peripheries to lymph node
What is the main type of Pattern recognition receptor (PRR)?
TOLL LIKE RECEPTOR (TLR)
What are the products of TLR stimulation ?
Increased cytokine prodc and transcription
Cytokine signalling
Recruitment of immune cells from circulation
What are the products of resident macrophages stimulation ?
Release of vasoactive molecules
Stimulation of endothelial cells and leucocyte
How does neutrophil leave blood during NO INFECTION?
BINDS TO SLIG AND FLOWS OUT
How does Neutrophil move in infected tissue ?
Cytokine from macrophages makes endothelial cells sticker
ENDOTHELIAL CELLS PRODUCE E-SELECTIN
SLIG BINDS TO E- SELECTIN
Neutrophil ROLLS
How does neutrophil move in a tissue receiving signal from infected tissue ?
Complement fragmets released from infected tissue causes neutrophils to produce INTEGRINS
INTEGRINS have CD18 causes to bind with ICAM and stops Neutrophil
What is Diapedesis ?
Platelet Endothelial cell adhesion molecules (PECAM)
Causes neutrophils to squece through endothelial spaces
What is chemotaxix ?
Attracting molecules such as C5a and FMET causes neutrophil to to move toward the infected site
What are the features of inflammation ?
Rubour
Tumour
Calor (warmth)
Dolor (pain)
Loss of function
What are the function of opsonins ?
Enhances Phagocytosis
(C3b) complement opsonins
(IgG) antibody opsonins
CRP
MBL
What is the end product of ROS which is in beach ?
Hypochlorite (HCLO-)
What is the other name of Human MHC ?
Human leukocyte Antigen
(HLA)
Function of MHC class 1 ?
Expressed on cell surface
Antigen to CD8 (cyt t cell)
MHC CLASS 2 Function ?
Present on Antigen Presenting cells (Dendritic cells)
Antigen to CD4 (T-help)
Hoe do b cell become plamsa cells and memory cells ?
After contact with Antigen and receiving help from T help cell
Immunoglobulin that secrete antibody on mucous memberane and can be a dimer or monomer
IgA
Only antibody to cross placenta
IgG
1st responding immunoglobin ?
IgM
Immunoglobulin that’s a receptor of B CELL ?
IgD
Immunoglobulin that binds to mast cell and basophils that also reacts to allergy and worm infections?
IgE
How is NK cells activated and how does it kill?
Activated by IFN-1 AND PRODUCE IFN-2 taht stimulates Phagocytosis.
What produces the don’t kill receptor for NK CELLS ?
MHC CLASS 1—> KIR
ABSENCE OF CLASS 1 —-> KAR
What is Fas ligands (FasL) ?
TYPE OF SUICIDE OF NK CELLS WHICH ACTIVATES SELF DESTRUCTION.
