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HOAD BLOCK 1 > 2.Sensing Danger (PAMP&PRP) > Flashcards

2.Sensing Danger (PAMP&PRP) Flashcards

1
Q

What are the soluble PRR ?

A

MBL
FICOLINS
CRP
C1Q

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2
Q

What are the membrane bound PRR ?

A

DECTIN 1
MACROPHAGE MANNOSE RECEPTOR
DC-SIGN
SCAVENGER RECEPTOR

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3
Q

What are the Intracellular receptor ?

A

TLR
NLR
RNA HELICASS (RIG-1&MDA)

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4
Q

Cell surface TLR ?

A

12456

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5
Q

Endosomal TLR ?

A

379

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6
Q

What does TLRs activate ?

A

APF
IRF
NF-KB

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7
Q

What does nod like receptors activate ?

A

NFK-B = CYTOKINES

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8
Q

Which does TLR3 AND TLR4 RECOGNISE?

A

3—> DS RNA—> IFN-1
4—-> SS RNA —-> IFN -1

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9
Q

What does RIG-1 LIKE HELICASE DETECT ?

A

CYYOSOMAL VIRQL RNA
STIMULATES IFN

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10
Q

How does RIG LIKE HELICASE DIFFERENTIATED PATHOGENIC FORM AND SELF RNA ?

A

5-TRIPHOSPHTE & DSRNA

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11
Q

What are the function of type 1- IFN INDUCTION?

A

ACTIVATES HELICASE CELLS TO KILL VIRUS
INDUCE ANTIVIRAL STAGE

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12
Q

How does IFN induce antiviral stage ?

A

Produces 3 enzymes

2,5oas - Activates RNASE-L

Induction of Rnase-L -Mrna degradation

Induction of PKR - term of protein synth

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13
Q

What is redundancy ?

A

Similar function of 2 or more cytokine in a same target cells

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14
Q

What pathway does IL AND IFN WORK ON?

A

JAK STAT

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15
Q

Which CD MARKER causes SCID?

A

CD132

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16
Q

What chain does CD-132 CONTAIN ?

A

IL-2R GAMMA

17
Q

What pathway do chemoattractants use ?

A

G-protien and MAPK

18
Q

What are the 4 types of Adhesion molecules ?

A

ICAM- INTEGRIN
SELECTIN & ADRESSIN

HOAD BLOCK 1 (3 decks)

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