introduction to haematological malignancies

Question 1

pathogenesis of haematological malignancy

Answer 1

multistep process
acquired genetic alterations in a long lived cell
proliferative/ survival advantage to that mutated cell
produces malignant clone
malignant clone grows to dominate tissue

Question 2

somatic hypermutation

Answer 2

b cell matches antigen presented by the dendritic cell

Question 3

indications for FFP use

Answer 3

replacement of coagulation factors due to major haemorrhage
DIC bleeding
thrombotic thrombocytopenic purpura
replacement of coaguation factor deficiencies where factor deficient

Question 4

would you transfuse FFP

Answer 4

VIII deficiency- no use factor concentrate
Factor V deficiency- yes
warfarin- IV vitamin K
DOAC- yes
DIC- yes