autoimmunity Flashcards
1
Q
Genetic factors
A
B27- ankylosing spondylitis
DR2- Good pasture syndrome
DR3- Sicca syndrome
2
Q
autoimmunity
A
ankylosing spondylitis
affects more males
3
Q
organ specific A.I
A
Endocrine glands
4
Q
pemphigus and pemphigoid
A
Pemphigus affects the outer of the skin (epidermis) and causes lesions and blisters that are easily ruptured. Pemphigoid affects a lower layer of the skin, between the epidermis and the dermis, creating tense blisters that do not break easily. Sometimes pemphigoid may look like hives or eczema without blisters.
5
Q
SLE
A
DNA specific T cells escape the thymus
T cell help and low level antibodies against DNA
-infection leading to apoptosis and interferon secretion
DNA/antibody complexes
6
Q
problem
A
non specific
suppress immune system
