Introduction to brain and behaviour Flashcards

1
Q

What influences behaviour?
(4 things)

A

Behavioural traits due to evolutionary and genetic influences

Behavioural traits due to environmental and social influences (eg. is a person displaying a particular behaviour because the others around them are doing this behaviour)

Behaviour based on current motivational state of the animal. (eg. if an animal is hungry/ stressed what are they more or less likely to do)

Behavioural traits based on previous experience

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2
Q

What is brain and behaviour?

A

The processes in the brain that lead to a particular behaviour

A biological perspective on how the brain controls behaviour

Requires thinking about and understanding brain function on a number of levels

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3
Q

A hierarchy of organisation

A
  1. Levels are connected
  2. Any manipulation at any level can change the function at other and at all levels of the hierarchy

We can change how the cells and brains are working and then can interpret the particular behaviour of the whole organism- changing any levels can change the outcome/ behaviour.

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4
Q

Levels of structures

A
  • Whole brain
  • Brain Circuits
  • Brain Regions
  • Cells (neurons and glia)
  • Organelles (synapses/axons)
  • Protein complexes
  • Proteins
  • Genes

Using a perspective that we are made by building blocks that are perhaps different cells that carry a specific and unique code. These cells are creating different organs and different regions and we have the brain with different circuits that are talking to one another. There is constant communication.

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5
Q

How is our genetic makeup and our brains dictating behaviour?

A

Our behaviour, environment, experiences also have an impact on our genes and gene expression. In turn, these change our brains which can change our behaviour.

Constant interaction of our biology, building blocks and hierarchy with our environment and then our environment feeds back and its a constant interaction.

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6
Q

The building blocks of the brain

A

Neurodevelopment Genetics
|
Neurophysiology:
Neurotransmission & Neuromodulation
Molecular aspects of L&M
Pain
|
Behaviour:
Social behaviour
Sleep & circadian rhythms
Typical & atypical
Functioning

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7
Q

Facts about the brain

A
  • Brain weight at birth weighs about 350g whereas in adulthood it is about 1300g
  • There are about 85 billion neurons and trillions of synapses in the mature brain
  • At the peak of neurogenesis, 250,000 neurons are born per minute!
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8
Q

Prenatal Development Stages

A
  1. Germinal Stage (1-2w)
  2. Embryonic Stage (3-8w)
  3. Fetal Stage (9-38w)
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9
Q

Prenatal Development Overview

A

All the processes begin mostly before birth

Germinal is a primitive, basic stage

Embryonic stage- all action taking place occurs after 3rd week of gestation. All organs of body are starting to form until week 9 which is fetal stage.

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10
Q

Germinal stage

A
  1. The nuclei of the egg and the sperm fuse to form a zygote. (ovum is zygote- fertilised egg)
  2. Zygote starts to divide at 12h, by a process called cleavage, to form a cluster of homogeneous cells - morula.
  3. The morula continues to divide to form a blastocyst (200-300 cells).
    (blastocyst- collection of different cells that have already travelled down the fallopian tube)
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11
Q

When does the embryonic stage begin?

A

Once implantation in the uterus takes place, the embryonic stage begins.

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12
Q

Embryonic Stage: Gastrulation
- initially?
- what forms?
- what happens structurally?

A
  • Initially – embryonic disc
  • Uneven rate of cell development forms three distinct layers:
    1. Ectoderm (upper)
    2. Mesoderm (middle)
    3. Endoderm (bottom)
  • The ectoderm will fold in itself to form the neural tube which will eventually become the nervous system

(The differentiation of different layers of these formation. The way these layers differentiate dictates what is going to become the brain, the body and so on.)

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13
Q

Process of gastrulation

A

When the neural crest starts to swallow, it kind of falls on itself and forms a hole in the centre which is called the central canal.

The neural tube is really what is going to become the brain.

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14
Q

Formation of the Nervous System

A

Swelling in middle

Then it falls on itself and starts to zip up

Top of neural tube will start to develop and become the brain where as the bottom part starts to create the midbrain and the hindbrain and then the spinal cord.

Neural tube starts to shape itself and differentiate and then look like a brain. All of these processes are dictated by genes.

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15
Q

Neural Tube Defects
Interaction between and influences from?

A

Constant interaction between what our genes dictate and the environment. The environment for the embryo is the placenta and the mums body. Whatever stimuli mums process or whatever they ingest (food, alcohol, nicotine) is transferred through the placenta and umbilical cord into the body.

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16
Q

Neural Tube Defects
2 things

A

Spina bifida

Failure of the closure of the neural fold at the level of the spinal cord
— 1 in 1000 live births
— small openings can often be surgically corrected
— larger opening can lead to paralysis and limb deformities
— Can be prevented by folic acid supplements
— Can happen if there is a lack of vitamin - B9

Anencephaly

Brain fails to develop
— generally results in stillborn

17
Q

What are the stages of brain development?

A
  1. Cell birth/ Proliferation (Neurogenesis and Gliogenesis)
  2. Cell migration
  3. Cell differentiation and maturation
  4. Synaptogenesis and synaptic pruning
  5. Cell death
  6. Myelination (myelogenesis)
18
Q

Timeline of brain development (prenatal onwards)
Order the following:
differentiation, neurogenesis, myelination, migration

A

1- Neurogenesis (cell death and glia)
2- Migration (cell death and glia)
3- Differentiation (cell death and glia)
4- Myelination (synaptogenesis and pruning)

All of these processes are beginning early on in the prenatal brain but some do continue throughout life.

19
Q

Impact of Experience on Synapse Formation

A

Experience expectant (Greenough and Black, 1992)

Development will not happen unless an experience happens during its critical period (the result of evolution and genes) and it is species-specific

Experience dependent are not predetermined but are generated in response to the environment

Vary between individuals i.e rats in complex environments have more synapses and more new neurons than the ones in standard conditions

20
Q

Key points from video on brain development

A
  • By 24 weeks, vital organs of fetus are well formed. The heart can beat on its own. The brain has nearly its full compliment of billions of neurons creating connections.
  • first phase of brain wiring= the brain follows a precisely specified genetic blue print
  • second phase of brain wiring= placing a specific phone call. If connections are met and get used, they are strengthened. If they’re only being used occasionally, they’re lost.
  • Field brain is a dynamic structure that is constantly changing in response to this process of strengthening appropriate connections and pruning inappropriate connections.
  • Eventually there will be trillions of connections with electric and chemical energy.
  • For a child learning to read, even a single letter will set off a complex series of reactions.
  • Learning- changing weights of connections in the brain depending upon experience.