INTRODUCTION TO BIOINFORMATICS Flashcards
With this, we can submit the discovered biological data and store and organize such data
Bioinformatics
It is a field which uses computers to store and analyze molecular biological information
Bioinformatics
It is about finding and interpreting biological data online.
Bioinformatics
It is the application of tools of computation and analysis to the capture and interpretation of
biological data
Bioinformatics
Give the 3 principal components of Bioinformatics
- Creation of databases
- The development of algorithms and statistics
- The use of these tools for the analysis and interpretation of various types of biological data
They are repository or like banks, this is where we store or gather biological information
Databases
These are designed to collect, archive, visualize, or arrange the biological information
Databases
It helps or enables the scientist in the retrieval of data that they will be needing for their research
Databases
It serves as a benchmark in the ongoing discovery of the molecular basis for disease, and this is the groundwork for molecular diagnostics
Human genome project
It is a branch of bioinformatics that study about RNA molecules in a living organisms
Transcriptomics
In this branch of bioinformatics, the genomes of bacteria, viruses, fungi, or parasites are described within a specific environment
Microbiomics
In this branch of bioinformatics, it involves the description of the chemical processes involving metabolites
Metabolomics
In this branch of bioinformatics, it describes the sequences of the WHOLE genome of an organisms
Genomics
In this branch of bioinformatics, it describes the entire complement of proteins in the entire organisms
Proteomics
it is done in a computer instead of a real laboratory
In silico
Protein Database in USA
RCSB PDB
This databases contains original data in the form or primary sequence data or structural data as submitted by the scientific community
Primary Databases
This database contain biomolecular data in its original form.
Primary databases
This database contains information that has been processed and derived from the raw data available in primary database
Secondary database
Contains data derived from the results of
analyzed primary data or from the raw data.
Secondary databases
It is a way of rearranging sequences of DNA, RNA, or protein to identify regions of similarity
Sequence alignment
It is the known sequence
reference sequence
It is the unknown sequence
query sequence
give the 2 types of sequence alignment
Pairwise and multiple
Give the tools used in pairwise
EMBOSS Water and BLAST
Give the tools used in Multiple Sequence alignment
MUSCLE, MAFFT, CLUSTAL Omega
A type of pairwise sequence alignment that Matching the residues (bases or amino acids)
of two sequences across their entire length
Global Aalignment
it Matches the identical sequences from 5’ to 3’
Global Alignment
The two sequences are treated as potentially equivalent
Global Alignment
It represents gap, which means there is presence in the first sequence and the second has none
dash line
it means the first sequence is identical/similar to second sequence
Straight line
A type of pairwise sequence alignment that Matching of two sequences from regions
which have more similarity with each other
Local Alignment
In this type of pairwise sequence, the two sequences may or may not be related
Local Alignment
True or False:
In global alignment, the whole
sequence is aligned, whereas in local alignment, only a portion/part is aligned.
True
In EMBOSS WATER, dissimilar bases are indicated by?
dot
It is the analysis of more than two sequences
Multiple Alignment Tools
It is a multiple sequence alignment tool that is used to directly compare the sequences to one another
CLUISTAL OMEGA
in clustal omega, same color in one column means?
Similar
It is a multiple sequence alignment tool that arranges the sequences of DNA, RNA, or protein to identify regions of similarity
MUSCLE
This tool is used to find regions of local similarity between sequences
BLAST (Basic Local Alignment Search Tool)
It is used to compare the unknown sequence with the database
Blast
nucleotide to nucleotide aligment
Blastn
protein to protein alignment
Blastp
