Introduction To Ageing Flashcards
What is aging
Progressive physiological changes in an organism, that lead to senescence or a decline of biological functions and of the organisms ability to metabolic stress
What is multimorbidity
Co-occurrence of multiple disease at the same time, in the same person. As people age they are more likely to experience several conditions at the same time
What is frailty
Characterised by diminished strength, endurance and reduced physiologic function, increasing a persons vulnerability to dependency and/or death
What factors can influence healthy ageing
Socioeconomic status
Working conditions
Social networks
Birth weight
Diet
Lifestyle
Access to healthcare
Growth and development
When is rate of ageing accelerated
Low socioeconomic status
Lives in a polluted area
Poor housing
Harsh working conditions
High stress levels
Lack of nutrition
Unfair treatment due to race or gender
What is geoscience
A research paradigm based in addressing the biology of ageing and the biology of age-related diseases together
What is the promise of geroscience
Expanding the years of health while compressing the years of sickness
What is a key driver of senescence and ageing in humans
Telomere shortening
Why do senescent cells accumulate with ageing
More cells enter senescence
Inefficient clearance by the immune system
Senescent cell evasion of immune surveillance
Inflammation driven paracrine senescence
