Introduction

Question 1

What does the activity of the nervous system depend on?

Answer 1

Ion channels

Question 2

What does this describe: the ability of an agonist to evoke response

Answer 2

efficacy

Question 3

What type of molecules are receptors?

Answer 3

Macromolecules

Question 4

What does this describe: the strength of association between ligand and receptor

Answer 4

Affinity

Question 5

What is the concentration of agonist that elicits a half maximal response termed?

Answer 5

The EC50

Question 6

What type of plot to pharmacologists use for the EC50?

Answer 6

Semi-logarithmic plot

Question 7

How is the relationship between concentration and response described?

Answer 7

Sigmoidal (s-shaped)

Question 8

In competitive antagonists, in which direction is the response curve shifted?

Answer 8

Parallel to right

Question 9

In non competitive antagonists, in which direction is the response curve shifted?

Answer 9

Does not shift

Question 10

What happens to the slope with competitive antagonists?

Answer 10

Remains same shape

Question 11

What happens to the slope with non competitive antagonists?

Answer 11

Decreases

Question 12

In which type of antagonist does EC50 and therefore potency increase?

Answer 12

Competitive

Question 13

Can you increase the effect on a non competitive antagonist by increasing the concentration of the agonist?

Answer 13

No