Elementary Pharmokinetics

Question 1

What is the critical concentration a drug must reach known as?

Answer 1

Minimum Effective Concentration (MEC)

Question 2

What is the range of concentration which can be used known as?

Answer 2

Therapeutic Window

Question 3

What therapeutic ratio (index) is classed as safe?

Answer 3

More than 10

Question 4

What order of kinetics do most drugs exhibit?

Answer 4

1st, where rate of elimination is directly proportional to drug concentration

Question 5

What does concentration of a drug at a certain time depend on?

Answer 5

Kel

Question 6

How is Kel related to half life?

Answer 6

inversely

Question 7

Does doubling dose of a drug displaying first order kinetics double the half life?

Answer 7

No

Question 8

How can the exponential curve produced by plotting Cp versus t be made linear?

Answer 8

By a log transformation

Question 9

What is clearance?

Answer 9

Theoretical volume of liquid from which a drug is totally removed in unit time

Question 10

If you increase volume of distribution, what happens to rate of drug elimination?

Answer 10

Decreases

Question 11

What is Css and what does it depend on?

Answer 11

Plasma steady state concentration, depends on balance between drug input and drug output

Question 12

In what type of drugs is the Css linearly related to infusion rate?

Answer 12

Drugs that exhibit 1st order kinetics

Question 13

Is infusion rate determined by half life?

Answer 13

No

Question 14

Is Css determined by half life?

Answer 14

Yes

Question 15

What order of kinetics are anti-epileptic drugs?

Answer 15

0

Question 16

What rate are 0 order kinetics drugs eliminated at?

Answer 16

constant rate, rather than one proportional to concentration