Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Hemostasis > intro. to secondary hemostasis > Flashcards

intro. to secondary hemostasis Flashcards

1
Q

Where are the coagulation factors active/inactive and what is their overall purpose?

A

Coagulation proteins (Factors)

  • Blood – inactive state
  • Once activated – interact to form fibrin clot
  • Purpose – to reinforce the plt plug
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Where are the coagulation factors produced?

A

All factors are produced in the liver

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is the name for factor I?

A

Fibrinogen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is the name for factor II?

A

prothrombin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is the name for factor III?

A

Tissue factor or tissue thromboplastin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is the name for factor IV?

A

Ionized calcium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is the name for factor V?

A

Labile factor or proaccelerin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is the name for factor VII?

A
  • stable factor (Serum prothrombin conversion accelerator SPCA),
  • proconvertin
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is the name for factor VIII?

A

antihemophilic factor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is the name for factor IX?

A

Christmas factor, plasma thromboplastin component, or antihemophilia factor B

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is the name for factor X?

A

Stuart-Prower factor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is the name of factor XI?

A

plasma thromboplastin antecedent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is the name of factor XII?

A

hageman factor or contact factor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is the name of factor XIII?

A

fibrin stabilizing factor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is another name for Fitzgerald factor?

A

high molecular weight kinogen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is another name for Fletcher factor?

A

prekalikrein

17
Q

Which factor is the main substrate?

A

Fibrinogen

18
Q

Which factors are cofactors?

A
  • Factor V (labile factor)

- VIII:C (antihemophilic factor (AHF))

19
Q

Which factors are serine proteases?

A

Serine proteases – cut peptide bonds

Includes all except XIII (IIa,VIIa, IXa, Xa, XIa, XIIa, prekallikrein)

20
Q

Which factor is a transaminase?

A

XIIIa-creates cross-links to stabilize clots

21
Q

Which factors are contact proteins?

A

XII – Hageman factor
XI – plasma thromboplastin antecedent
Prekallikrein – Fletcher factor
High-molecular weight kininogen (HMWK) – Fitzgerald factor

22
Q

Which factors are vitamin k dependent?

A

2, 7, 9, 10

23
Q

Which vitamin k dependent factor has the shortest half life?

A

7 & is most sensitive levels of coumarin therapy

24
Q

What are the vit. K dep. Inhibitors?

A

Prot. C & S

25
Q

what do Vit K deficient patients-have decreased production of ?

A

functional prothrombin proteins

& inhibitors

26
Q

what do Coumarin, Coumadin, Warfarin inhibit?

A

Vit. K reduction yielding inactive factors

27
Q

what test monitors coumadin therapy?

A

pt

28
Q

what are Acquired Vit K deficiencies – common, seen in ?

A
  • post surgical procedures
  • high dose antibiotic use
  • liver disease
29
Q

which factors are Fibrinogen or Thrombin sensitive proteins

A

I
V
VIII:C
XIII

30
Q

Which group does thrombin act on?

A

all the factors in the fibrinogen group

  • Enhances activity of factors V & VIII:C
  • Activates factor XIII
  • Converts fibrinogen to fibrin
31
Q

what are the Procoagulant effects of Thrombin ?

A
    • feedback: Factor V & VIII
  • Converts Factor I to soluble fibrin monomer (cleaves fibrinopeptides A & B)
  • Activates XIII (cross-links fibrin monomers)
  • Induces plt activation & aggregation by promoting —secretion of serotonin & TXA2
32
Q

what are the Coagulation inhibitor effects of thrombin?

A
  • Binds to Antithrombin (AT), If heparin present AT enhanced 200x ‘s
  • Promotes release of t-PA (Tissue Plasminogen Activator)
  • Binds to thrombomodulin – activates Protein C (neg. feedback on Va & VIIIa)
33
Q

how does Thrombin Initiates Tissue Repair?

A
  • Induces chemotaxis

- Stimulates proliferation of smooth muscle & endothelial cells

Hemostasis (5 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions