crossword study guide exam 2 Flashcards
What measures prothrombin activity in serum after coagulation has taken place?
prothrombin consumption
A whitish filamentous protein/clot formed by the action of thrombin and fibrinogen
fibrin
A screen for all types of circulating anticoagulants based on the ability of normal plasma to correct an abnormal clotting time with a factor deficiency
mixing studies
commercially prepared concentrate to the vitamin K dependent factors in lyophilized form, used to treat some hemorrhagic disorders
prothrombin complex
inherited deficiency of factor VIII:C
Hemophilia A
procoagulant portion of factor VIII complex
Factor VIII:C
congenital deficiency of factor VIII:vWF and secondarily factor VIII:C resulting in mucocutaneous hemorrhagic disorder
Von Willebrands Disease
Genetic characteristic located on the X or Y chromosome
Sex linked
Test used to distinguish between factor VII and factor X deficiency
Stypven time
Substance used to delay or prevent clotting
anticoagulant
system that contains factors XII, XI, IX, and VIII, leads to the common pathway and is surface (contact) activated
intrinsic
Term of genetic inheritance in which a characteristic cannot be expressed unless it is carried by both members of a homologous set of chromosomes
recessive
Factor IX deficiency
Hemophilia B
Single donor therapeutic plasma product containing all clotting factors
Fresh Frozen plasma
Acquired inhibitors of normal coagulation, directed against a specific factor or a complex of factors
circulating anticoagulant
Factor VIII:C
anti hemophiliac factor
Factor V deficiency
parahemophilia
Factor II
prothrombin
“easy” bleeder, mostly men
hemophiliac
process of stopping blood flow from a wound
coagulation
prothrombin is the substrate for formation of this substance
thrombin
trait with moderate bleeding diathesis in which PT is normal, APTT is slightly prolonged and is not corrected by incubation and levels of all known coagulation factors are normal
Passovoy
High Molecular Weight Kininogen
Fitzgerald
Pathway containing factors X,V,II,I
Common
Factor that stabilizes the soluble fibrin gel
FSF
Factor VII
Proconvertin
Deficiency causes parahemophilia
Proaccelerin
Stuart-Prower factor
Factor X
Deficiency of this, primarily found in Ashkenazi Jews and sonsanguineous relationships, causes hemophilia C
PTA
Process by which body controls clotting and bleeding
hemostasis
Thrombin acts on this to form fibrin
fibrinogen
Measures intrinsic system activity, examples are Lee-White and Hemochron
Whole blood clotting time
System containing factor VII
extrinsic
substance which, in the presence of ionized calcium, converts factor VII to VIIa
tissue thromboplastin
disorder in which fibrinogen is qualitatively abnormal
Dysfibrinogenemia
Factors II, VII, IX, and X are dependent on sufficient quantities of this for production in the liver
vitamin K
disorder manifesting decreased levels of fibrinogen
hypofibrinogenemia
presence of this may lead to thrombosis
Lupus anticoagulant
test monitoring the extrinsic system
pro thrombin time
substance extracted from the venom of a snake Bothrops atrox; used in coagulation procedure to resolve discrepant results when the thrombin time is prolonged due to heparin
reptilase
factor IX
Christmas Factor
test that monitors the conversion of fibrinogen to fibrin
Thrombin time
Prekallikrein is also known as?
Fletcher factor
substance used as a surface activator in APTT testing
kaolin
substance that acts as a contact activator causing the release of PF3 and the activation of the intrinsic system
Celite
