coagulation cascade

Question 1

What test measures the extrinsic pathway and what reagents are used?

Answer 1

• pt

- thromboplastin and calcium

Question 2

What type of anticoagulant effects the extrinsic pathway?

Answer 2

coumadin

Question 3

What initiates the extrinsic pathway?

Answer 3

by tissue factor (provides a phospholipid surface not normally found in blood) as it enters the vascular system

Question 4

What does tissue factor activate?

Answer 4

factor VII

Question 5

What does factor VII activate?

Answer 5

factor X (common pathway)

Question 6

When factor II is activated what does it positively feedback to?

Answer 6

factor XI (intrinsic)

Question 7

how does the common pathway begin?

Answer 7

activation of factor X

Question 8

what factors are part of the intrinsic pathway?

Answer 8

12 → 11 → 9 → 10(common)

need 8 for 9 to activate 10

Question 9

what factors are part of the extrinsic pathway?

Answer 9

3 → 7 → 10

Question 10

what factors are part of the common pathway?

Answer 10

10-5-2-1-13