Intro to Rheum Flashcards

1
Q

Mechanisms of self tolerance? (3)

A

Clonal deletion
Clonal anergy
Peripheral Suppression by T-cells

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2
Q

Induction of Anti-Self Responses? (3)

A

Loss of Suppression
Modification by external agent
Alteration of self-antigen

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3
Q

Gene most frequently implicated in autoimmunity problems?

A

PTPN-22, results in excessive lymphocyte activation via defective protein tyrosin phosphatase

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4
Q

What causes Chron’s disease?

A

NOD-2 cytoplasmic sensor of microbes in epithelial cells

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5
Q

RA associated with what genetic markers?

A

HLA DR4 and DR1

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6
Q

Cell mediated immunity to what can cause RA?

A

Type 2 collagen

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7
Q

Key features of RA?

A

Pannus
Joint Space loss
Juxta-Articular bone erosion

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8
Q

What is Rheumatoid factor?

A

Antibodies to autologous IgG immunoglobulin

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9
Q

RF critical cause of RA?

A

No

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10
Q

What is Felty’s syndrome?

A

Rheumatoid arthritis
Splenomegaly
Neutropenia

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11
Q

In RA what joints are most often affected?

A

Symmetrical Disease

Lumbosacral spine, hips usually spared

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12
Q

In what tissue layer are rheumatoid nodules found?

A

Subcutaneous tissues

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13
Q

How do you measure Rheumatoid factor?

A

Measured by agglutination of latex particles coated with IgG

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14
Q

What differentiates Juvenile RA from regular RA? (3)

A

Oligoarthritis more common
Systemic onset more frequent
RF, nodules usually absent

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15
Q

What is Ankylosing Spondylitis?

A

Chronic inflammatory joint disease involving axial joints especially sacroiliac joints. Marie-Stumpell disease

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16
Q

What genetic component is Ankylosing spondylitis associated with?

17
Q

Diagnostic features of Ankylosing spondylitis?

A

RF -

Joint distribution

18
Q

What is a specific pathology associated with Ankylosing spondylitis?

A

Loss of spinal mobility

Ossification

19
Q

What is Reiter’s syndrome?

A

Arthritis following nongonococcal urethritis, cervicitis, conjunctivitis, or following GI disorder.

20
Q

Diagnostic features of Reiter’s syndrome?

A

RF -

Joint distribution

21
Q

What joints does Reiter’s syndrome go to?

A

Ankles, knees, and feet

22
Q

Enteropathic Arthritis associated with what?

A

Inflammatory bowel disease

23
Q

Patients with Ulcerative colitis or Crohn’s disease can experience what with Enteropathic Arthritis?

A

Migratory oligoarthritis of large joints and spine

24
Q

Clinical features of Psoriatic arthritis?

A

DIP of hands, and feet Asymmetrically

25
Diagnostic features of Psoriatic arthritis?
Psoriasis | RF -
26
Specific Pathologic features of psoriatic arthritis?
Sausage finger, inflammation of tendon sheaths
27
What is infectious Arthritis?
Acute infectious suppurative inflammation of a joint
28
Problem associated with TB and weight bearing joints?
Potts disease
29
In gout what are deposition of masses of rates in joints and other sites called?
Tophi
30
Predisposing factors for Gout?
Heavy alcohol Obesity Drugs (thiazides)
31
What kills people with gout?
Progressive renal disease
32
What is psuedogout?
Calcium pyrophosphate crystal deposition disease
33
Most common type of joint disease?
Osteoarthritis
34
What do you see in Osteoarthritis as the main clinical feature?
Heberden's nodes
35
Specific pathologic feature of osteoarthritis?
Cysts in bone