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pathology starting with vasculitis > Charts of Rheum > Flashcards

Charts of Rheum Flashcards

1
Q

Name of nodules for RA?

A

Rheumatoid nodules

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2
Q

Nodules for Gout?

A

Tophus, tophi

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3
Q

Nodules for osteoarthritis?

A

Heberden’s nodes

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4
Q

Distribution for RA?

A

Cutaneous lesions found in skin overlying pressure points; can also occur in viscera

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5
Q

Distribution for Gout?

A

Articular cartilage of joints and periarticular ligaments; also occur in tendons, soft tissues, and ear lobes

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6
Q

Distribution for Osteoarthritis?

A

Distal interphalangeal joints

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7
Q

Appearance of RA?

A

Non-tender, round/oval nodules in subcutaneous tissues.

Fibrinoid necrosis with palisading epithelia histiocytes, adjacent lymphocytes and plasma cells

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8
Q

Appearance of Gout?

A

Large firm nodules found adjacent to involved joints, superficial top associated with ulceration of overlying skin

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9
Q

Appearance of Osteoarthritis?

A

Juxta-articular osteophytes

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10
Q

Pathogenesis of RA?

A

Deposition of immune complexes probably involving RF

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11
Q

Pathogenesis of Gout?

A

Aggregates of rate crystals surrounded by foreign body reaction involving macrophages, lymphocytes, and foreign body giant cells

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12
Q

Pathogenesis of Osteoarthritis?

A

Bony outgrowths

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13
Q

Who does osteoarthritis occur in?

A

Women, but not men

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14
Q

Inciting reaction for RA?

A

Immune response against self antigens

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15
Q

Immune mechanism for RA?

A

Cell mediated to type 2 collagen

RF-IgG immune complexes

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16
Q

Pathology for RA?

A

Fibrosis
Pannus formation
Joint destruction

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17
Q

Clinical association of RA?

A

HLA B27, DR1
EBV
RF: IgM anti-IgG

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18
Q

Inciting reaction of Juvenile RA?

A

Immune response against self antigens

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19
Q

Immune mechanism of JRA?

A

Cell mediated to type 2 collagen

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20
Q

Pathology of JRA?

A

Fibrosis
Pannus
Joint destruction

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21
Q

Clinical association of JRA?

A

ANA +

No RF

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22
Q

Inciting reaction of Ankylosing spondylitis (AKS)?

A

Immune response against self antigens

23
Q

Immune mechanism of ASK?

A

Cell mediated response to joint elements secondary to infection

24
Q

Pathology of ASK?

A

Chronic arthritis

Spondylosis

25
Q

Clinical association of ASK?

A

HLA B27

26
Q

Reiter’s syndrome (RS) inciting reaction?

A

Immune response against self antigens

27
Q

RS immune mechanism?

A

Cell mediated response to elements secondary to infection

28
Q

Pathology of RS?

A

Chronic arthritis

29
Q

Clinical association of RS?

A

Prior Gentiourinary infection

80% HLA B27 +

30
Q

Inciting reaction of Systemic Lupus Erythrematosus (SLE)?

A

Immune response against self antigens

31
Q

Immune mechanism of SLE?

A

Types 2 and 3 hypersensitivity

32
Q

Pathology of SLE?

A

Nonerosive synovitis
PMNS
Fibrin

33
Q

Clinical association of SLE?

A

HLA DR2, DR3

34
Q

Gout inciting reaction?

A

Immune response against uric acid crystals

35
Q

Immune mechanism of gout?

A

Acute inflammation

Chronic lesions with granulomatous reaction

36
Q

Pathology of gout?

A

Inflammation reaction to crystals
PMNs
Granulomatous inflammation

37
Q

Clinical associations of Gout?

A

Genetic
Hyperuricemia
Tophi

38
Q

Inciting reaction of post strep arthritis?

A

Cross reactive immune response against strep

39
Q

Immune mechanism of post strep arthritis?

A

Immune complex type 3

Possibly type 2

40
Q

Pathology of Post strep Arthritis?

A

Acute inflammatory response

PMNs

41
Q

Clinical association with Post strep Arthritis?

A

Prior infection with Group A Strep

Rheumatic Fever

42
Q

Serum sickness inciting reaction?

A

Immune response variety of antigens

Vaccines

43
Q

Immune mechanism of serum sickness?

A

Immune complex Type 3 with acute inflammation

44
Q

Pathology of Serum sickness/

A

Acute inflammatory response

PMNs

45
Q

Clinical association of serum sickness?

A

Conditions which result in Ab:Ag complex formation

46
Q

Inciting reaction of suppurative arthritis?

A

Seeding of joints with bacterial organims

47
Q

Immune mechanism of Suppurative Arthritis?

A

Acute inflammation

48
Q

Pathology of Suppurative Arthritis?

A

Inflammation reaction to organism

PMNs

49
Q

Clinical association of Suppurative Arthritis?

A

Normal or deficiency of C5, C6, or C7

50
Q

Inciting reaction of Osteoarthritis?

A

Chronic inflammatory response to joint erosion

51
Q

Immune mechanism of Osteoarthritis?

A

Chronic inflammation

52
Q

Pathology of Osteoarthritis?

A

Chronic inflammation reaction

Reactive Chondrocytes

53
Q

Clinical associations of Osteoarthritis?

A

Idiopathic

Trauma

pathology starting with vasculitis (7 decks)

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