Charts of Rheum

Question 1

Name of nodules for RA?

Answer 1

Rheumatoid nodules

Question 2

Nodules for Gout?

Answer 2

Tophus, tophi

Question 3

Nodules for osteoarthritis?

Answer 3

Heberden’s nodes

Question 4

Distribution for RA?

Answer 4

Cutaneous lesions found in skin overlying pressure points; can also occur in viscera

Question 5

Distribution for Gout?

Answer 5

Articular cartilage of joints and periarticular ligaments; also occur in tendons, soft tissues, and ear lobes

Question 6

Distribution for Osteoarthritis?

Answer 6

Distal interphalangeal joints

Question 7

Appearance of RA?

Answer 7

Non-tender, round/oval nodules in subcutaneous tissues.

Fibrinoid necrosis with palisading epithelia histiocytes, adjacent lymphocytes and plasma cells

Question 8

Appearance of Gout?

Answer 8

Large firm nodules found adjacent to involved joints, superficial top associated with ulceration of overlying skin

Question 9

Appearance of Osteoarthritis?

Answer 9

Juxta-articular osteophytes

Question 10

Pathogenesis of RA?

Answer 10

Deposition of immune complexes probably involving RF

Question 11

Pathogenesis of Gout?

Answer 11

Aggregates of rate crystals surrounded by foreign body reaction involving macrophages, lymphocytes, and foreign body giant cells

Question 12

Pathogenesis of Osteoarthritis?

Answer 12

Bony outgrowths

Question 13

Who does osteoarthritis occur in?

Answer 13

Women, but not men

Question 14

Inciting reaction for RA?

Answer 14

Immune response against self antigens

Question 15

Immune mechanism for RA?

Answer 15

Cell mediated to type 2 collagen

RF-IgG immune complexes

Question 16

Pathology for RA?

Answer 16

Fibrosis
Pannus formation
Joint destruction

Question 17

Clinical association of RA?

Answer 17

HLA B27, DR1
EBV
RF: IgM anti-IgG

Question 18

Inciting reaction of Juvenile RA?

Answer 18

Immune response against self antigens

Question 19

Immune mechanism of JRA?

Answer 19

Cell mediated to type 2 collagen

Question 20

Pathology of JRA?

Answer 20

Fibrosis
Pannus
Joint destruction

Question 21

Clinical association of JRA?

Answer 21

ANA +

No RF

Question 22

Inciting reaction of Ankylosing spondylitis (AKS)?

Answer 22

Immune response against self antigens

Question 23

Immune mechanism of ASK?

Answer 23

Cell mediated response to joint elements secondary to infection

Question 24

Pathology of ASK?

Answer 24

Chronic arthritis

Spondylosis

Question 25

Clinical association of ASK?

Answer 25

HLA B27

Question 26

Reiter's syndrome (RS) inciting reaction?

Answer 26

Immune response against self antigens

Question 27

RS immune mechanism?

Answer 27

Cell mediated response to elements secondary to infection

Question 28

Pathology of RS?

Answer 28

Chronic arthritis

Question 29

Clinical association of RS?

Answer 29

Prior Gentiourinary infection | 80% HLA B27 +

Question 30

Inciting reaction of Systemic Lupus Erythrematosus (SLE)?

Answer 30

Immune response against self antigens

Question 31

Immune mechanism of SLE?

Answer 31

Types 2 and 3 hypersensitivity

Question 32

Pathology of SLE?

Answer 32

Nonerosive synovitis PMNS Fibrin

Question 33

Clinical association of SLE?

Answer 33

HLA DR2, DR3

Question 34

Gout inciting reaction?

Answer 34

Immune response against uric acid crystals

Question 35

Immune mechanism of gout?

Answer 35

Acute inflammation | Chronic lesions with granulomatous reaction

Question 36

Pathology of gout?

Answer 36

Inflammation reaction to crystals PMNs Granulomatous inflammation

Question 37

Clinical associations of Gout?

Answer 37

Genetic Hyperuricemia Tophi

Question 38

Inciting reaction of post strep arthritis?

Answer 38

Cross reactive immune response against strep

Question 39

Immune mechanism of post strep arthritis?

Answer 39

Immune complex type 3 | Possibly type 2

Question 40

Pathology of Post strep Arthritis?

Answer 40

Acute inflammatory response | PMNs

Question 41

Clinical association with Post strep Arthritis?

Answer 41

Prior infection with Group A Strep | Rheumatic Fever

Question 42

Serum sickness inciting reaction?

Answer 42

Immune response variety of antigens | Vaccines

Question 43

Immune mechanism of serum sickness?

Answer 43

Immune complex Type 3 with acute inflammation

Question 44

Pathology of Serum sickness/

Answer 44

Acute inflammatory response | PMNs

Question 45

Clinical association of serum sickness?

Answer 45

Conditions which result in Ab:Ag complex formation

Question 46

Inciting reaction of suppurative arthritis?

Answer 46

Seeding of joints with bacterial organims

Question 47

Immune mechanism of Suppurative Arthritis?

Answer 47

Acute inflammation

Question 48

Pathology of Suppurative Arthritis?

Answer 48

Inflammation reaction to organism | PMNs

Question 49

Clinical association of Suppurative Arthritis?

Answer 49

Normal or deficiency of C5, C6, or C7

Question 50

Inciting reaction of Osteoarthritis?

Answer 50

Chronic inflammatory response to joint erosion

Question 51

Immune mechanism of Osteoarthritis?

Answer 51

Chronic inflammation

Question 52

Pathology of Osteoarthritis?

Answer 52

Chronic inflammation reaction | Reactive Chondrocytes

Question 53

Clinical associations of Osteoarthritis?

Answer 53

Idiopathic | Trauma