Charts of Rheum 2 Flashcards

1
Q

Drug induced Lupus (DIL) type of immune injury?

A

Type 2 and 3

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2
Q

DIL manifestation?

A

Immune complex, disease of vessels, glomeruli
Loss of blood cells
Renal and CNS involvement UNCOMMON

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3
Q

Pathogenesis of Drug induced lupus?

A

Drug reaction to hydrazine, procainamid, isoniazid, D-penicillamine

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4
Q

ANA/HLA associations of DIL?

A

Antihistones

HLA-DR4

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5
Q

Discoid lupus (DL) pathogenesis?

A

Dysregulation of immune response/UV light

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6
Q

Immune mechanism of DL?

A

Immune comples and complement deposits along skin

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7
Q

Type of immune injury is DL?

A

Type 3

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8
Q

Manifestation of DL?

A

Limited to skin

Rare systemic symptoms

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9
Q

Diffuse scleroderma (DS) pathogenesis?

A

Excessive deposition of collagen due to immune activation

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10
Q

Immune mechanism of DS?

A

CD4 cells stimulate cytokine production and fibrosis in skin ad other organs.
There is also blood vessel fibrosis

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11
Q

HLA/ANA associations for DS?

A

DNA topoisomerase 1 (Scl-70)

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12
Q

Type of immune injury is DS?

A

Type 4 due to Cytokine stimulation of fibrosis, endothelial activation

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13
Q

Manifestations of DS?

A

Fibrosis of dermis, esophagus, lungs

Vascular injury to kidneys

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14
Q

Pathogenesis of Limited Scleroderma (CREST)?

A

Similar to DS but limited to skin of fingers, forearms, and face
Also calcification of subcutaneous tissues

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15
Q

Immune mechanism of CREST?

A

CD4 cells stimulate cytokine production and fibrosis in skin, organs, and blood vessels

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16
Q

HLA/ANA associations of CREST?

A

Anti-centromere

17
Q

Type of immune injury is CREST?

A

Cytokine stimulation of fibrosis, type 4

18
Q

Manifestations of CREST?

A
Calcinosis
Raynaud's
Esophageal dysfunction
Sclerodactyl 
Telangiectasia
19
Q

Sjogrens syndrome pathogenesis?

A

Tissue specific response triggered by retrovirus HTLV or EBV infection

20
Q

Immune mechanism of Sjogren?

A

CD4 response to auto antigen such as cytoskeletal protein alpha fodrin

21
Q

HLA/ANA associations of Sjogren?

A

Anti-RNP (Ribonucleoprotein)

Multiple HLA-DR and DQ

22
Q

Type of immune injury for Sjogren?

23
Q

Manifestation of Sjogren?

A

Cell mediated destruction of lacrimal and salivary glands with fibrosis

24
Q

Pathogenesis of Dermatomyositis?

A

Activation of CD4 cells leading to antibody formation

25
Immune mechanism of Dermatomyositis?
Antibody and complement mediated vasculitis with secondary loss of muscle fibers
26
Type of immune injury for Dermatomyositis?
Type 3
27
Manifestation of Dermatomyositis?
Loss of small vessels in muscle with ischemic necrosis of muscle fibers
28
Pathogenesis of Polymyositis?
Activation of CD8 cells
29
Immune mechanism of Polymyositis?
Cell mediated destruction of myofibers
30
Type of immune injury for Polymyositis?
Type 4
31
Manifestation of Polymyositis?
Necrosis of muscle fibers
32
Pathogenesis of Inclusion body myositis (IBM)?
Activation of CD8 cells
33
Immune mechanism of IBM?
Unknown and immunosuppressive therapy isn't helpful
34
Type of immune injury for IBM?
Also unknown
35
Manifestation of IBM?
Necrosis of muscle fibers | Secondary immune response