Intro to Psychiatry - Anxiety and Anxiety-Related Disorders Flashcards

1
Q

When is fear pathologic?

A
  • When its out of proportion to risk/severity of threat
  • Response lasts beyond threat duration
  • Response becomes generalized to other situations
  • Social/occupational functioning impairment
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2
Q

“True” Anxiety disorders

A
  • Panic Disorder
  • Agoraphobia
  • Specific phobia
  • Generalized Anxiety Disorder
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3
Q

“Anxiety-like” disorders

A
  • OCD
  • PTSD
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4
Q

Type of anxiety disorder characterized by recurrent panic attacks?

A

Panic disorder

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5
Q

Criteria for panic disorder diagnosis?

A
  • need to have periods in between attacks where patient fears another attack OR does maladaptive things to avoid another one
  • Panic can’t be due to a phobia or other disorder
  • Must have at least 4 panic symptoms not due to an underlying medical disorder
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6
Q

Generalized worry that occurs more days than not that is disproportionate to the severity of the event that is feared

A

Generalized Anxiety Disorder

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7
Q

Diagnostic criteria for GAD?

A
  • Excessive anxiety more days than not for 6 months
  • Difficulty controlling the anxiety
  • Accompanied by at least 3 of the diagnostic symptoms
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8
Q

Unreasonable fear of being out-of-doors, being in a crowd, being in a place where they can’t escape, or may suffer from embarassement?

A

Agoraphobia

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9
Q

How long does the fear or anxiety need to be present for agoraphobia to be diagnosed?

A

6 months

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10
Q

Fears of specific objects or situations that go beyond the true threat of the stimulus and cause avoidance and functional impairment?

A

Specific phobias

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11
Q

Diagnostic criteria for specific phobias? (6)

A
  • exposure to phobia results in immediate fear/anxiety
  • phobia actively avoided
  • fear is out of proportion
  • person recognizes it as excessive
  • significantly impacts daily functioning
  • Must be present for > 6 months
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12
Q

Persistent (> 6mo.) fear of social or performance situations?

A

Social anxiety

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13
Q

When does PTSD happen?

A
  • Exposure to actual death, threatened by death, physical or sexual violence, serious injury
  • Frequently associated with combat in men
  • Frequently associated with abuse in women
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14
Q

Intrusion symptoms of PTSD?

A

Intrusive, distressing memories, flashbacks, dreams

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15
Q

Avoidance behaviour of PTSD?

A
  • Avoiding situations or events that are associated with the trauma
  • Can also involve avoiding people, places, or conversations
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16
Q

Cognitive and mood symptoms of PTSD?

A
  • memory deficits, negative emotions, guilt, shame
  • detachment from others, loss of interest in people or activities
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17
Q

Arousal and reactivity symptoms of PTSD?

A
  • Difficulty sleeping, exaggerated startle response
  • Anger, irritability, increased risk-seeking behaviour
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18
Q

Definition of an obsession?

A

intrusive and unwanted repetitive thoughts, urges, or impulses that lead to a marked increase in anxiety or distress

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19
Q

Definition of a compulsion?

A

repeated behaviours or mental acts that are done in response to obsessions, or in rigid-rule bound ways

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20
Q

Obsessions and compulsions in OCD must take up ________/day or cause what?

A

1 hour/day; cause significant distress or impairment in social, occupational, or other areas of function

21
Q

What is it called when patients are aware that their obsessions and compulsions are illogical and not based on fact?

22
Q

Other disorders that share a similar neurobiology to OCD?

A
  • hoarding disorder
  • skin-picking disorder or trichitomania
  • Body dysmorphic disorder
23
Q

Fear response initial steps?

A

Activation of locus coeruleus (LC) that releases norepinephrine (NE)

24
Q

Result of LC activation and increase release of NE?

A
  • Activation of amygdala = emotional fear response
  • Activation of hypothalamus = SNS and cortisol release
  • Activation of reticular activating system = increased arousal
25
When the hippocampus is involved/activated, what is its role?
Learning about the cause of the fear and how it can be avoided
26
Important pathways that can "cross-talk" to each other in the brain
Noradrenergic, serotonergic, and dopaminergic
27
Normal anxiety and fear response?
Locus coeruleus and amygdala activated => SNS and temporary release of cortisol to help us deal with threats
28
Areas activated or inactivated in abnormal anxiety and fear response?
Stria terminalis (near amygdala), dorsal raphe nucleus, and LC
29
What are the results of abnormal anxiety and fear response?
- poorer regulation of mood, worry/fear by PFC - Excessive cortisol release and SNS activation
30
OCD pathogenesis likely involves circuits that involve what?
Basal ganglia
31
Input nuclei? Functions?
- putamen (limb/trunk movement) - caudate (cognition and eye movement) - nucleus accumbens (emotional reg)
32
Associated nuclei? Function?
- Globus pallidue externa - Substantia nigra pars compacta - Subthalamic nucleus *all limb/trunk, eye movement; and emotional reg*
33
Output nuclei? Functions?
- Globus pallidus interna (putamen function) - Substantia nigra pars reticulata (caudate function)
34
Epidemiology of eating disorders
F>M (10:1)
35
Higher risk individuals for an eating disorder?
- "perfectionist" traits - Hx of sexual abuse - feelings of lack of control in other dimensions of life - Expectations regarding weight
36
Anorexia diagnostic criteria?
- intake and weight: energy intake < requirement = low body weight - fear or behaviour: fear of gaining weight/avoiding gaining weight - perception: body dysmorphia
37
Bulimia diagnostic criteria?
- recurrent episodes of binge eating - recurrent inappropriate compensatory behaviour to prevent weight gain - binge/compensation = at least 1 time wky for 3 mo - self-evaluation based on body shape and weight
38
Benzodiazepines act as _____ and _______. Examples of each?
- Anxiolytics (Diazepam) - Hypnotics (Triazolam)
39
Benzo mechanism of action?
Facilitate binding of GABA to GABA-R
40
Hangover effect?
- wake up feeling groggy - more common with long half-life agents
41
Early morning rebound effect?
- wake up too early - more common with short half-life agents - can lead to taking second pill => tolerance development
42
Tolerance?
Usual dose of a drug no longer sufficient to get therapeutic effect
43
What may cause tolerance of a benzo?
Down-regulation of GABA-R
44
Dependance?
Brain requires the drug to generate normal amounts of GABA activity - leading to more severe withdrawal sx
45
Mild benzo withdrawal sx?
- extra-sensory awareness - muscle twitching and tremor - rebound excitation
46
Severe benzo withdrawal sx?
- increased BP, HR, temp - rage - hallucinations and paranoia - seizures
47
Competitive inhibitor of benzos?
Flumazenil
48
Why use Flumazenil?
- remove effects of benzo once therapeutic effects no longer needed - treatment of benzo OD