INTRO TO PHARMACOKINETICS

Question 1

Pharmacodynamics definition

Answer 1

How a drug works/ what a drug does

Question 2

Pharmacokinetics definition

Answer 2

When a drug works/ is activated; at what time and at what concentration

Question 3

What is the therapeutic window?

Answer 3

The difference between the effective concentration and the toxic concentration

Question 4

What the abbreviation regarding pharmacokinetic research and what does it stand for?

Answer 4

ADME- too
A - Absorption
D - Distribution
M - Metabolism
E - Excretion

A+D refer to the mechanisms of how the drug gets to the site of action

M+E refer to how the drug is removed from the site of action

Question 5

What are the routes of administration?

Answer 5

• Entral
• Parentral
• Percutaneous

Question 6

What factors affect the absorption of a drug?

Answer 6

• One compartment model
• Diffusion - is it passive or active?
• Blood flow at site of admin
• Route of administration
• Bioavailability
• Drug solubility
• Dose of drug

Question 7

Explain the one compartment model

Answer 7

When a drug enters the body, it diffuses everywhere and is equilibrated. This allows it to eventually reach the target receptors and carry out changes to the bio system

Question 8

Explain passive diffusion with regards to drug absorption

Answer 8

Passive - Drug diffuses through:
- sheets of cells forming epithelia
- intracellular pores - found in some blood vessels for the diffusion of small water soluble molecules

Question 9

Explain pinocytosis

Answer 9

molecules that travel through membrane via active transport and facilitated diffusion. They are vesicles that are taken up and released on the other side