INTRO TO PHARMA Flashcards
First began when a human first used ____to relieve symptoms of disease
plants (herbal medicine).
recorded the earliest surviving “prescriptions” on clay tablets in 3000 BC.
Babylonians
recorded the Pen Tsao (Great Herbal), a 40-volume compendium of plant remedies dating to 2700 BC
Chinese
(Great Herbal), a 40-volume compendium of plant remedies
Pen Tsao
Chinese recorded the Pen Tsao (Great Herbal), a 40-volume compendium of plant remedies
2700 BC
Babylonians recorded the earliest surviving “prescriptions” on clay tablets
3000 BC.
earliest surviving prescriptions
clay tablets
archived their remedies on a document known as Eber’s Papyrus.
Egyptians
Egyptians archived their remedies on a document known as Eber’s Papyrus.
1500 B.C.
an ancient medical document that contains over 842 remedies for illnesses and injuries
Eber’s Papyrus
Eber’s Papyrus contains over ____ remedies for illnesses and injuries
842
Pharmacologia sen Manuductio and Materiam Medicum is by
Samuel Dale
first recorded reference to the word pharmacology was found
Pharmacologia sen Manuductio and Materiam Medicum by Samuel
Samuel Dale’s Pharmacologia sen Manuductio and Materiam Medicum
1963
study of herbal medicines. A term that persisted into the early 20th century.
Materia Medica
Materia Medica is a term that persisted into the ____
early 20th century.
Modern Pharmacology Started in
early 1800’s
Chemists isolate these active agents’
morphine, colchicine, cocaine
During this time, chemists isolate active agents’
Modern Pharmacology
isolated morphine from opium
Frederich Serturner
Frederich Serturner isolated morphine from opium
1805
first department of pharmacology was established. in
Estonia
first department of pharmacology was established. in Estonia in
1847
father of American pharmacology and founded first pharmacology department in the United States at the University in Michigan 1890.
John Jacob Abel
John Jacob Abel founded first pharmacology department in the
United States at the University in Michigan
John Jacob Abel founded first pharmacology department in
1890
Hundreds of new drugs can be synthesized and tested for a short time.
20th Century
It became possible to understand how drugs produced their effects, down to their molecular mechanism of action.
20th Century
Derived from two Greek words: Pharmacon means “medicine” and Logos means “study”.
Pharmacology
Study of medicine
Pharmacology
Branch of medicine concerned with the prevention of disease and treatment of suffering.
Therapeutics
Application of drugs for the purpose of disease prevention and treatment of suffering
Pharmacotherapeutics
- Drugs or Medications
- Biologics
- Complementary and Alternative Therapies
Classification of Therapeutics Agents
chemical agent capable of producing biological responses within the body
Drugs or Medications
responses may be desirable (therapeutic) or undesirable (adverse).
Drugs or Medications
refers to response after a treatment of any kind, the result of which are judged to be useful or favorable.
Therapeutic Effect
an undesired harmful effect resulting from a medication or other intervention
Adverse Effect
Are agents naturally produced in animal cells by microorganism or by the body itself.
Biologics
Used to treat wide variety of illness
Biologics
•Natural plant extracts
• Herbs
• Vitamins
• Minerals
• Dietary supplement
Complementary and Alternative Therapies
➢ Acupuncture
➢Hypnosis/Hypnotherapy
➢ Biofeedback
➢ Therapeutic Massage
Complementary and Alternative Therapies EXAMPLES
treats patients by insertion and manipulation of needles.
Acupuncture
Minimally invasive method to stimulate nerve-rich areas of the skin surface to influence tissues, organs, and various functions of the body
Acupuncture
Mental state (state theory) or imaginative role-enactment (non-state theory).
Hypnosis/Hypnotherapy
Induced by a procedure known as hypnotic induction, which is commonly composed of a long series of preliminary instructions and suggestions
Hypnosis/Hypnotherapy
Measurement of physiological responses that yields information about the relationship between the mind and the body and helps clients learn how to manipulate those responses through mental activity.
Biofeedback
Application of pressure and motion by the hands with the intent of improving the recipient’s well-being.
Therapeutic Massage
- Plants
- Animals
- Minerals and mineral products
- Chemical substances
Sources of Drugs
digitalis, opium, belladonna
Plant Source
epinephrine, insulin
Animals Source
iron
Minerals and mineral products Source
made in the laboratory.
Chemical substances Source
- Prescription drugs
- OTC
- Investigational Drugs
- Illicit or “Street” Drugs
Classification of Drugs
- Prescribe by a doctor
- Bought in the pharmacy
- Prescribed and intended to be used by one person
Prescription drugs
An order of medication or other forms of therapy which specifies precisely the name of the drug and the dosage regimen to be used by the client or patient for whom it may concern.
Prescription
- Order must be given
- HCP can examine the client
- Dx is established
- Practitioner can order for the proper dug and can control the amt and frqncy.
- Client can be taught how to use the drug and its side effects.
Prescription drugs
Does not require a physician’s order
OTC
They may treat themselves safely if they carefully follow instructions included in the medication.
OTC
Subjected to clinical studies to evaluate the usefulness of the drug in treating the disease for which it is claimed to be effected
Investigational Drugs
These drugs are used and or distributed illegally
Illicit or “Street” Drugs
Heroin, stimulants, cocaine, marijuana
Examples of Illicit or “Street” Drugs
- Formulary
- U.S. Pharmacopoeia (USP)
Drug Regulations and Standards
List of drugs and drug recipes
Formulary
First standard commonly used by pharmacist
Formulary
Medical reference summarizing standards of drug purity, strength, and direction for synthesis
U.S. Pharmacopoeia (USP)
The first comprehensive publication of drug standards in US, was established in 1820.
U.S. Pharmacopoeia (USP)
U.S. Pharmacopoeia was established in
1820
Regulatory Acts, Standards, and Organizations
- Bureau of Food and Drugs (BFAD)
- Food and Drug Administration (FDA)
Was created under the Philippines Department of Health as the regulatory and enforcement organization for all food, drug, cosmetic, and related products.
Bureau of Food and Drugs (BFAD)
Was officially established as an agency of the U.S. Department of Health and Human Services.
Food and Drug Administration (FDA)
- Center for Drug Evaluation and Research (CDER)
- Center for Biologics Evaluation and Research (CBER)
Branches of the FDA
Branch of the FDA, exercises control over whether prescription drugs and OTC drugs may be used for therapy
CDER
Branch of FDA, that regulates the use of biologics including serums, vaccines, and blood products.
CBER
- Preclinical Investigation
- Clinical Investigation
- Review of the New Drug Application (NDA)
- Post marketing Surveillance
4 Phases of Therapeutic Drugs and Biologics
Involves extensive laboratory research
Preclinical Investigation
Studies performed in several species of animals to examine the drugs’ effectiveness at different doses and to look for adverse effects
Preclinical Investigation
The second stage of drug testing, takes place in 3 different stages termed clinical phase trials
Clinical Investigation
The longest part of the drug approval access
Clinical Investigation
Third stage of the drug approval process
Review of the New Drug Application (NDA)
This stage, clinical phase III trials and animals may continue depending on the results obtained from the preclinical testing.
Review of the New Drug Application (NDA)
The final stage of the drug approval process begins after clinical trials and the NDA review have been completed
Post marketing Surveillance
The purpose of this stage is to survey for harmful drug effects in a larger population
Post marketing Surveillance
➢ Therapeutic Classification
➢ Pharmacological Classification
➢ Mechanism of Action
Drug Classes and Schedule
organizing drugs based on their therapeutic usefulness in treating a particular disease.
Therapeutic Classification
refers to the way an agent works at the molecular, tissue, and body system level.
Pharmacological Classification
how drugs produce its effect in the body.
Mechanism of Action
Influence blood clotting
Anticoagulant
Lower blood cholesterol
Antihyperlipidemics
Lower blood pressure
Antihypertensive
treat angina
Antianginals
restore normal cardiac rythym
Antidysrythmics
- Anticoagulant
- Antihyperlipidemic
- Antihypertensive
- Antianginals
- Antidysrhythmic
ex according to Therapeutic Classification
- Diuretic
- Calcium Channel Blocker
- Angiotensin Converting enzyme inhibitor
- Adrenergic-antagonist (blocker)
- Vasodilator
ex according to Pharmacological Classification
Lowers Plasma Volume
Diuretic
Blocks heart calcium channels
Calcium Channel Blocker
Blocks hormonal activity
Angiotensin Converting enzyme inhibitor
Blocks physiologic reax to stress
Adrenergic-antagonist (blocker)
Dilates peripheral blood vessels
Vasodilator
Helpful in predicting a substance physical and chemical properties
Chemical Name
Conveys clear and concise meaning about the nature of the drug, they are often complicated and difficult to remember or pronounce
Chemical Name
Describes the drug’s chemical nature
Chemical Name
o Lithium carbonate
o Calcium gluconate
o Sodium chloride
Chemical Name examples
Less complicated and easier to remember
Usually, lower cased
Generic Name
Only one generic name for each drug, health care providers often use this name
Generic Name
Is the official nonproprietary name for the drug.
Generic Name
Assigned by the company marketing the drug
Trade Name/Brand Name
Also called proprietary or product or brand name
Trade Name/Brand Name
Usually capitalized
Trade Name/Brand Name
contains more than one active generic ingredients.
Combination drug
Combination drug
Trade Name/Brand Name
Physiological ability of the drug to reach its target cells and produce its effects.
Bioavailability
Drug whose use is restricted by the Controlled Substances Act of 1970.
Controlled Substance
Controlled Substance use is restricted by
Controlled Substances Act of 1970.
generally a drug or chemical whose manufacture, possession, or use are regulated by a government
Control substance
refers to the overwhelming feeling that drives someone to use drugs repeatedly
Addiction
physiological or psychological need for a substance.
Dependence
refers to an altered physical condition caused by the adaptation of the nervous system to repeat drug use
Physical Dependence
the individual expresses physical signs of discomfort when the drug is no longer available.
Withdrawal
the individual feels an intense compelling desire to continue drug use.
Psychologically Dependent
Drugs that have a significant potential for abuse.
Scheduled Drugs
Therap use is limited or none
DS 1
Therapeutically used w/ precription
DS 2,3,4
Therapeutically used w/o precription
DS 5
Highest, high,high
DS 1
high, high. high
DS 2
Mod, mod, high
DS 3
lower, lower, lower
DS 4
lowest, lowest, lowest
DS 5
Heroin
Isd
Marijuana
Methaqualone
DS 1 examples
Morphine
Cocaine
Methadone
Methamphetamines’
DS 2 examples
Steroids
Codeine
Hydrocodone w/ aspirin or Tylenol
Some barbiturates
DS 3 examples
Dextropropoxyphene
Pentazocine
Meprobamate
Diazepam
Alprazolam
DS 4 examples
OTC
Cough meds w/ codeine
DS 5 examples