Intro to HIV

Question 1

How is HIV transmitted

Answer 1

Sexual contact
Injection drug use
Pregnancy, childbirth, and breast feeing
Occupational exposure
Blood transfusion/organ transplant

Question 2

2 important proteins in the HIV structure

Answer 2

Gp 120 (docking protein)
p24 (capsid protein)

Question 3

3 critical enzymes for HIV lifecycle

Answer 3

Reverse transcriptase
Integrase
Protease

Question 4

What are 3 symptoms/diseases you get with a CD4 count

1. Under 500
2. Under 200
3. Under 100
4. Under 50

Answer 4

1. Weight loss, herpes zoster, lymphadenopathy
2. Pneumocystic pneumonia, TB, esophageal candidiasis
3. CNS lymphoma, cryptococcal meningitis, extra-pulmonary TB
4. CMV disease, PML, MAC

Question 5

3 reasons why you want to reduce viral replication

Answer 5

Restore and preserve immune function
Reduce HIV transmission
Reduce chronic inflammation and its consequences

Question 6

ART should include what drugs?

Answer 6

2 NRTIs

And 1 either NNRTI, protease inhibitor, or integrase inhibitor

Question 7

Pre-Exposure prophylaxis

Answer 7

Tenofovir/Emtricitabine
1 tablet daily for HIV negative people
For high risk people
Main side effect is nephrotoxicity

Question 8

90-90-90 goal

Answer 8

90% of all people living with HIV will know their status
90% of all living with HIV will receive ART
90% of all receiving ART will have viral suppression
This will allow us to end the AIDS epidemic by 2030

Question 9

2 theoretical ways to cure HIV

Answer 9

Viral eradication

Viral remission

Question 10

Viral eradication methods to cure HIV

Answer 10

Reverse latency and destroy the reservoir
Bone marrow transplants from someone with immunity
Gene therapy