Intro To Glaucoma Flashcards
T/F: Glaucoma is defined by the presence of elevated IOP
False
What age range is considered juvenile glaucoma?
4-35
If a pt’s age falls below the age range for JOAG, what is it type of GLC is it considered?
Congenital
What is the difference between POAG, SOAG, PACG, and SACG?
POAG — idiopathic GLC, (-) systemic association, angle is open
SOAG — GLC due to increased resistance in TM outflow, angle is open
PACG — GLC due to pupillary block, caused by configuration of ant seg (angle is closed bc of pt’s anatomy)
SACG — GLC due to angle closure (≥ 180º of ITC) secondary to ocular or systemic disorder
TRUE/FALSE: it is possible to have ACG without a pupillary block.
TRUE; e.g. ciliary body cyst/tumor, scleral buckle, etc.
Give 2 examples of how someone might have mixed-mechanism GLC.
- A patient previously diagnosed with POAG, whose angle later becomes narrow
- A pt previously/successfully treated for narrow angle (e.g. LPI) still exhibits reduced outflow
What anatomical structure deformity is likely to cause congenital GLC?
High insertion of anterior uvea
Define preperimetric GLC.
(+) glaucomatous nerve damage
(-) VD defects
What’s demographic is more likely to get POAG?
Black/Latino myope
What’s demographic is more likely to get PACG?
Asian/Inuit hyperope
What is the gene associated with POAG?
GLC1A TIGR/MYOC
What is the gene associated with Pseudoexfoliation?
LOXL1
There is a higher concordance of GLC in _____ vs _____ twins. What does this suggest?
Monozygotic»_space; Dizygotic
Suggests genetic component in GLC
In GLC, preferential loss in what type of axons?
Large, inf/sup poles, magnocellular pathway
Studies suggest that RGC’s in GLC die by ____
Apoptosis
