Intro to endocrine (8) Flashcards
Do endocrine hormones have high sensitivity or low sensitivity receptors?
high
What hormones does the fetal placenta produce and what are the effects?
- HCG –> corpus leuteum produces estrogen and progesterone
- human placental lactogen- GH, prolactin actions
- Estrogens, progesterone
What are the three classifications of hormones?
polypeptides, amines, steroids
Why are thyroid hormones weird?
derived from AAs but behave like steroids
Describe for steroid hormones:
- storage pools
- location of receptor
- regulation target
- half life
- no storage pools - produced on demand
- cytoplasm or nucleus
- regulate gene transcription
- hours to days
Describe for peptide hormones:
- storage pools
- location of receptor
- regulation target
- half life
- secretory vesicles for storage
- bind to receptor on membrane
- signals a transduction cascade
- seconds to minutes
What is pseudohypoparathyroidism?
abnormal a3 subunit of G protein for PTH
low ca2+, high Phosphorous
increased PTH
What glands secrete hormones that are released in a cyclical fashion?
hormones from the hypothalamus and pituitary
What is another word for the anterior pituitary and posterior pituitary?
anterior - adenohypophysis
posterior - neurohyophysis
What is the blood supply of both sections of the pituitary?
- anterior - venous blood
2. posterior - arterial
What nuclei in the hypothalamus contact the posterior pituitary?
supraoptic nucleus, PVN
What hormones are released from the posterior pituitary? What are their fuctions?
oxytocin: targets uterus and breast tissue
- involved in labor during child birth
vasopressin: collecting duct to inc water permeability
GHRH Name the:
- target cell of the anterior pituitary
- hormone released
- peripheral target
- somatotrophic cells
- GH
- targets multiple tissues
TRH Name the:
- target cell of the anterior pituitary
- hormone released
- peripheral target
- thyrotrophic cells
- TSH
- thyroid follicular cells - thyroid hormone
CRH Name the:
- target cell of the anterior pituitary
- hormone released
- peripheral target
- corticotrophic cells
- ACTH
- fasiculate and reticularis cells of adrenal cortex to release corticosteroids