Intro to endocrine (8) Flashcards

1
Q

Do endocrine hormones have high sensitivity or low sensitivity receptors?

A

high

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What hormones does the fetal placenta produce and what are the effects?

A
  1. HCG –> corpus leuteum produces estrogen and progesterone
  2. human placental lactogen- GH, prolactin actions
  3. Estrogens, progesterone
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What are the three classifications of hormones?

A

polypeptides, amines, steroids

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Why are thyroid hormones weird?

A

derived from AAs but behave like steroids

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Describe for steroid hormones:

  1. storage pools
  2. location of receptor
  3. regulation target
  4. half life
A
  1. no storage pools - produced on demand
  2. cytoplasm or nucleus
  3. regulate gene transcription
  4. hours to days
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Describe for peptide hormones:

  1. storage pools
  2. location of receptor
  3. regulation target
  4. half life
A
  1. secretory vesicles for storage
  2. bind to receptor on membrane
  3. signals a transduction cascade
  4. seconds to minutes
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is pseudohypoparathyroidism?

A

abnormal a3 subunit of G protein for PTH
low ca2+, high Phosphorous
increased PTH

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What glands secrete hormones that are released in a cyclical fashion?

A

hormones from the hypothalamus and pituitary

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is another word for the anterior pituitary and posterior pituitary?

A

anterior - adenohypophysis

posterior - neurohyophysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is the blood supply of both sections of the pituitary?

A
  1. anterior - venous blood

2. posterior - arterial

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What nuclei in the hypothalamus contact the posterior pituitary?

A

supraoptic nucleus, PVN

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What hormones are released from the posterior pituitary? What are their fuctions?

A

oxytocin: targets uterus and breast tissue
- involved in labor during child birth

vasopressin: collecting duct to inc water permeability

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

GHRH Name the:

  1. target cell of the anterior pituitary
  2. hormone released
  3. peripheral target
A
  1. somatotrophic cells
  2. GH
  3. targets multiple tissues
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

TRH Name the:

  1. target cell of the anterior pituitary
  2. hormone released
  3. peripheral target
A
  1. thyrotrophic cells
  2. TSH
  3. thyroid follicular cells - thyroid hormone
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

CRH Name the:

  1. target cell of the anterior pituitary
  2. hormone released
  3. peripheral target
A
  1. corticotrophic cells
  2. ACTH
  3. fasiculate and reticularis cells of adrenal cortex to release corticosteroids
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

GnRH stimulating FSH release

Name the:

  1. target cell of the anterior pituitary
  2. peripheral target
A
  1. Gonadotrophs
  2. ovarian follicular cells - estrogen, progestins
    sertolic cells - initiate spermatogenesis
17
Q

GnRH stimulating LH release

Name the:

  1. target cell of the anterior pituitary
  2. peripheral target
A
  1. gonadotrophic cells
  2. ovarian follicles - make estrogen, progestins
    leydig cells to make testosterone
18
Q

Dopamine Name the:

  1. target cell of the anterior pituitary
  2. hormone released
  3. peripheral target
A
  1. inhibits lactotrophic cells
  2. PRL
  3. mammary glands - initiates and mantains milk production
19
Q

Can peptide hormones cross the BBB?

A

yeppers

20
Q

What drugs are used to treat hyperprolactinemia?

A

dopamine agonists (inhibit prolactin)

21
Q

What stimulates prolactin release?

A

TRH released from hypothalamus

22
Q

What are the functions of prolactin?

A
  • stim milk production during lactation
  • promotes breast dev during puberty & pregnancy
  • inhibits ovulation
23
Q

What is the major cause of oxytocin stimulating milk ejection ?

A

suckling

24
Q

What receptors does ADH interact with in the:

  1. kidney
  2. vascular smooth muscle
A
  1. V2

2. V1

25
Q

What will the urine be like if ADH is high?

A

low concentrated

26
Q

What medical condition results if ADH is too low?

A

diabetes inisipidus

27
Q

Mrs. mary lou vallno says: What causes more cases of hypopituarism, brain damage or pituitary adenomas?

A

brain damage