Intro to derm- functions of skin

Question 1

Which bacteria can be found in the skin, and which predominant? What is their role?

Answer 1

their role is to provide competitive protection from harmful bacteria (immune modulation and epithelial health). Mist common is actinobacteria, firmicutes (eg clostidria and bacilli staphylococcus) and proteobacteria

Question 2

What are the roles of the skin?

Answer 2

physical barrier, immune barrier, thermoregulation, sensation metabolic functions and aesthetic appearance (idiots play trumpets so mothers awake)

Question 3

Which cells are involved in the immunological function of the skin?

Answer 3

macrophages, langerhans cells (APCs)

Question 4

What do Tregs do?

Answer 4

regulate T cells in absence of danger

Question 5

What other immune cells help with immunological surveillance? Where are these found? Why are they here?

Answer 5

in dermis, macrophages, tissue-resident t-cells and dendritic cells

Question 6

What are defensins and cathelicidins? What is their function?

Answer 6

keratin-derived endogenous antibiotics, which provide defence against fungi, bacteria and viruses

Question 7

What features of the skin provide the skin the ability to act as a physical barrier?

Answer 7

Stratum corneum (water resistant), subcutaneous fat (cushions trauma), melanin (against UV light damage)

Question 8

What 3 features of the skin allow for thermoregulation?

Answer 8

hairs with erector muscles sweat glands, vasoconstriction and vasodilation.

Question 9

What are the metabolic functions of the skin?

Answer 9

produce precursor of vitamin D, subcutaneous fat, calorie reserve, leptin release (regulates hunger and energy metabolism)