INTRO TO CNS DISORDERS

Question 1

what are the 7 processes in neurotransmission?

Answer 1

1. neurotransmitter synthesis
2. stored in vesicles
3. degradation of any leaked neurotransmitter
4. action potential-dependent release
5. Neurotransmitter binds to postsynaptic receptors
6. neurotransmitter binds to presynaptic auto-receptors
7. neurotransmitter deactivated either by reuptake or degradation

Question 2

what is required for neurotransmitter release into the synaptic cleft

Answer 2

CALCIUM

Question 3

Glutamate - excitatory or inhibitory

Answer 3

excitatory

Question 4

GABA - excitatory or inhibitory

Answer 4

inhibitory

Question 5

examples of monoamines

Answer 5

dopamine
norepinephrine
serotonin

Question 6

aetiology of many CNS disorders

Answer 6

role of genetics
inflammation

Question 7

a disadvantage of CNS drugs having multiple targets

Answer 7

adverse effects

Question 8

types of symptoms

Answer 8

1. positive (hallucinations)
2. negative (withdrawals)
3. cognitive (disorganised thinking)