EPILEPSY Flashcards

1
Q

seizures

A

a transient occurrence of signs and/or symptoms due to abnormal excessive or synchronous neuronal activity in the brain

some seizures can hardly noticed, while others are totally disabling. generally depends on area of the brain in which the seizure occurs

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2
Q

epilepsy

A
  1. at least 2 unprovoked (or reflex) seizures occurring >24h apart
  2. one unprovoked (or reflex) seizure and a probability of further seizures similar to the general recurrence risk (at least 60%) after 2 unprovoked seizures, occurring over the next 10 years
  3. diagnosis of epilepsy syndrome
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3
Q

generalised seizures

A

arising within and rapidly engaging bilaterally distributed networks
(affects both hemispheres of the brain)

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4
Q

name all the generalised seizures (6)

A
  • tonic-clonic
  • absence
  • clonic
  • atonic
  • myoclonic
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5
Q

tonic seizures

A

cause all of your muscle to suddenly become stiff

you can lose balance and fall over

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6
Q

absence seizures

A
  • when you lose awareness of your surroundings for a short time
  • mainly affect children but can happen at any age
  • during the seizure the person may stare into space, flutter their eyes or make slight jerking movements
  • the seizure only lasts up to 15 seconds and you won’t be able to remember them
  • can happen several times a day
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7
Q

myoclonic seizures

A
  • where some or all of your body suddenly twitches or jerks, often happen soon after waking up
  • usually last only a fraction of a second, but can occur several times.
  • you normally remain awake
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8
Q

atonic seizures

A

cause all your muscles to suddenly relax, so you may fall to the ground

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9
Q

clonic seizures

A

cause the body to shake and jerk but not stiff (like muscle spasms)

typically last a few minutes and you might lose consciousness

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10
Q

tonic-clonic seizures

A

happens in 2 stages
1. tonic stage - you lose consciousness and body goes stiff
2. clonic stage - limbs jerk about, may lose control of bladder or bowel, might bite your tongue or the inside of your cheek, might have difficulty breathing

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11
Q

long-term consequences of status epilepticus

A

neuronal death
neuronal injury
alteration of neuronal networks

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12
Q

status epilepticus

A

condition resulting from either the failure of the mechanisms responsible for seizure termination or from the initiation of mechanisms which lead to abnormally prolonged seizures

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13
Q

symptoms of a simple partial (focal) seizure or ‘auras’

A

can cause
- general strange feeling
- ‘rising’ feeling in tummy
- deja vu
- unusual smells/tastes
- tingling in your arms or legs
- stiffness or twitching in part of the body (arm or hand)

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14
Q

simple partial (focal) seizures or ‘auras’

A

known as ‘warnings’ or ‘auras’ because they can be a sign that another type of seizure is about to happen

you remain awake and aware

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15
Q

complex partial (focal) seizures symptoms

A
  • smacking your lips
  • rubbing your hands
  • making random noises
  • moving your arms around
  • pick/fiddling
  • chewing or wallowing

you lose your sense of awareness and make random body movements

you will not have any memory of it

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16
Q

focal seizures

A

originating in networks limited to one hemisphere

may develop into bilateral convulsive seizures

17
Q

what causes epilepsy

A
  • genetic (Dravet’s syndrome - SCN1a)
  • structural (acquired or genetic)
  • metabolic (glucose transporter deficiency GLUT1)
  • immune (Rasmussen syndrome - autoimmune)
  • infectious (bacterial and viral encephalitis)
  • unknown (1/3 of all diagnosed)
18
Q

co-morbidities associated with epilepsy

A

stroke
migraine/headaches
dementia
traumatic brain injury
cerebral palsy
ASD
MS

19
Q

stage 1 - seizure sequence and underlying mechanism of epilepsy

A

initiation - abnormal voltage-gated channels

20
Q

stage 2 - seizure sequence and underlying mechanism of epilepsy

A

synchronisation - abnormal receptor-operated channels

21
Q

stage 3 - seizure sequence and underlying mechanism of epilepsy

A

propagation - recruitment of neurones via anatomical connections

22
Q

targets for the treatment of epilepsy

A
  • inihibition of voltage-gated Na+ channels
  • promote inhibitory neurotransmission
  • inhibition of voltage-gated Ca2+ channels
23
Q

drugs that inhibit voltage-gated sodium channels

A

phenytoin
carbamazepine
lamotrigine (Also HVA Ca2+ channels)
oxcarbazepine

24
Q

drugs that enhance GABA action

A

BZs - increase the frequency of opening of GABA A channels

phenobarbital - increase the probability of opening of GABA A channels

vigabatrin and tiagabine - inhibits GABA transaminase

25
Q

drugs that inhibit voltage gated calcium channels

A

ethosuximide (T-type Ca2+ channels - LVA)
pregabalin (HVA Ca2+ channels)
gabapentin (HVA Ca2+ channels)

26
Q

treating generalised seizures

A

1st line - sodium valproate
alternative - lamotrigine, topiramate
contraindications - Valproate & pregnancy

27
Q

treating focal seizures

A

1st line - lamotrigine
alternative - carbamazepine, levetiracetam
contraindications - patient dependent side effects

28
Q

treating absence seizures

A

1st line - ethosuximide
alternative - sodium valproate, lamotrigine
contraindications - patient dependent side effects

29
Q

treating status epilepticus

A

1st line - midazolam ducally or intranasally
alternative - lorazepam, diazepam
contraindications - patient dependent side effects

30
Q

what mechanisms does sodium valproate act on

A

Ca2+ channels
Na+ channels
GABA

31
Q

what mechanisms does levetiracetam act on

A

Ca2+ channels
GABA
synaptic vesicle release

32
Q

what mechanisms does felbamate act on

A

Ca2+ channels
Na+ channels
GABA
glutamate receptors

33
Q

what mechanisms does perampanel act on

A

glutamate receptors (AMPA)

34
Q
A