Intro to Anemia

Question 1

Answer 1

Spherocytes: round, smaller diameter, more densely staining, lack of central pallor

Question 2

Answer 2

Target Cells

Examples: Liver disease, splenectomy, hemoglobinopathies

Question 3

Answer 3

Elliptocytes (ovalocytes)

Examples: Hereditary elliptocytosis, megaloblastic anemia, iron deficiency

Question 4

Answer 4

Teardrop cells

Examples: Megaloblastic anemia, myelofibrosis, extramedullary hematopoiesis

Question 5

Answer 5

Sickled cells

Example: sickle cell disease

Question 6

Answer 6

Fragments (schistocytes)

Examples: TTP, DIC, HUS malignant hypertension

Question 7

Answer 7

Bite cells

Example: Oxidant hemolysis (G6PD deficiency)

Question 8

Answer 8

Normochromic

Question 9

Answer 9

Hypochromic

Question 10

Answer 10

Polychromasia (reticulocytes)

Question 11

Answer 11

Howell-Jolly Bodies (nuclear fragments)

Examples: Splenectomy, megaloblastic anemia

Question 12

Answer 12

Pappenheimer bodies (iron granules)

Splenectomy, iron overload

Question 13

Answer 13

Basophilic Stippling (coarse)

Examples: Thalassemias, MDS, lead poisioning

Question 14

Answer 14

Hemoglobin C Crystals

Examples: Hb CC disease, Hb SC disease

Question 15

Answer 15

Rouleaux

Decreased repulsive forces between RBCs

Examples: Increased serum proteins (Ig, fibrinogen)

Question 16

Answer 16

Agglutination

Example: IgM RBC antibodies (cold agglutinins)