Hematopoiesis Flashcards
1
Q
Multipotent CSF
A
Stem cell factor (SCF) binds c-Kit –> all myeloid & lymphoid CFUs
2
Q
Unipotent CSFs
A
Erythropoietin –> CFU-E (erythropoiesis)
Thrombopoietin –> CFU-Meg (thrombopoiesis)
G-CSF –> CFU-G (neutrophils)
M-CSF –> monocyte –> macrophage
3
Q
What are the 4 criteria that cells fit as they develop?
A
- Cell size – gets smaller
- Nuclear morphology
- Cytoplasm: changes from blue –> red
blue = RNA; red = protein - Specific granules
4
Q
WBC Diff
% Neutrophils
A
34-71%
5
Q
WBC Diff
% Lymphocytes
A
19-53%
6
Q
WBC Diff
% Monocytes
A
5-12%
7
Q
WBC Diff
% Eosinophils
A
0-7%
8
Q
WBC Diff
% Basophils
A
0-1%
9
Q
CBC normal values
WBC
A
4000 - 10,000 /uL
10
Q
CBC normal values
RBC
A
4,600,000-6,100,000 /uL
4.6 - 6.1x10^6 /uL
11
Q
CBC normal values
HGB
A
13.7-17.5 g/dL
12
Q
CBC normal values
HCT
A
40-51%
13
Q
CBC normal values
MCV
A
80-100 fL
14
Q
CBC normal values
Platelets
A
163,000 - 369,000 /uL
15
Q
Which myelocytes are CD45 negative?
A
Erythroid
Megakaryocytes
