Intro + PKPD

Question 1

Body Surface Area (BSA)

Answer 1

sqrt [(ht x wt) / 3600] = m^2

Question 2

CrCl (Bedside Schwartz)

Answer 2

(0.413 x ht) / Scr = mL/min/1.73m^2

Question 3

Max stability of water containing preparations in the fridge

Answer 3

14 days

Question 4

Injectable solutions admin orally?

Answer 4

Ok if both contain the same salt form with similar bioavailability

Question 5

Max pediatric dose

Answer 5

adult dose

Question 6

Ins units

Answer 6

mL/kg/day

Question 7

Outs units

Answer 7

mL/kg/hour

Question 8

Anuria

Answer 8

0 output

Question 9

Oliguria

Answer 9

< 0.5-1 mL/kg/hr

Question 10

Normal urine output

Answer 10

> 1 mL/kg/hr

Question 11

polyuria

Answer 11

> 4 mL/kg/hr

Question 12

why oral absorption decreases with age

Answer 12

higher gastric pH early in life and high rate of gastric emptying

Question 13

How higher total body water and extracellular fluid in neonates influences distribution

Answer 13

Higher Vd of hydrophilic drugs
Lower Vd of lipophilic drugs

Question 14

Protein binding

Answer 14

decreased concentrations of circulating proteins and binding affinity of albumin (increased free fraction drug)

Question 15

CYP3A4

Answer 15

Transition of 3A7 to 3A4
adult levels by age 1

Question 16

1A2

Answer 16

Absent in neonatal period
55% of adult by age 9

Question 17

Elimination implications

Answer 17

Slower clearance, longer half life
Less frequent dosing required