Drug Delivery and Dosage Forms + Calculations Flashcards
Chewable tablets pro
minimizes need for additional liquid
chewable tablets con
relies on ability to chew, can’t utilize ER, may not mask taste, may be difficult to control dose
minitablets pro
erase the need for swallowing tablets
minitablets con
limited dosage flexibility, maximum mg per tablet
ODT pro
allows for quick dissolving with no need for additional liquid
ODT con
can’t easily split or mask taste
ODF pro
can offer dose flexibility with strip cutting
ODF con
hard to mask taste, high cost
powder packet pro
eliminates need for crushing tablets, ready to use
powder packet con
may require significant volume to mix, not easily titratable
sprinkle capsule/graule pro
can ease in admin with food
sprinkle capsule/granule con
limit dose flexibility
benzoyl alcohol risk
neurotoxicity and metabolic acidosis
ex: IV lorazepam (2% benzoyl alcohol)
ethanol risk
neurotoxicity
ex: dexamethasone intensol solution (30% alcohol)
polysorbate risk
liver and kidney failure, thrombocytopenia, ascites, pulmonary deterioration
ex: IV amiodarone
propylene glycol risk
seizures, hyperosmolarity, metabolic acidosis, neurotoxicity
ex: IV phenobarbital (67.8 pg)
sorbitol risk
osmotic diarrhea
ex: loperamide
Gestational age (GA)
from conception (from first day of the mothers last menstrual cycle)
post natal age (PNA)
chronological age, since birthday
post menstrual age (PMA)
combo of GA and PNA
Neonate range
birth to 30 days
infant range
30 days to 1 year
child range
1 year to 12 years
adolescent range
12 years to 18 years
