Intro and Clinical Pharmakokinetics Flashcards
1
Q
Equation:
Volume of distribution =
A
Dose / plasma concentration
2
Q
CYP inducers
A
Reduces metabolisms of other medicines
- results in increased metabolism of drugs and leading to decreases in plasma concentrations of drugs with loss of therapeutic efficacy
- Certain drug like (ex: phenobarbital, rifampin, carbamazepine, phenytoin) are capable of inducing CYP isoenzymes
3
Q
CYP Inhibitor
A
Inhibits drug metabolism
- increases plasma drug concentration and adverse effects or drug toxicity
4
Q
Half life
A
How long medication stays in your system
Or
How long it takes to get out of your system
- depends on concentration and elimination.
Ex: if kidneys shut down, half life would increase
5
Q
Equation
Half life (t1/2)
A
= 0.693 x vd/cl
If Cl is high - t1/2 will be slower
If vd is high - t1/2 will be longer
6
Q
Hypoalbuminemia
A
Not having enough albumin in blood and the drugs have nothing to attach to it
7
Q
A
8
Q
A
9
Q
A
