Intrinsic Sympathomimetic Activity (ISA) Flashcards
1
Q
ISA?
A
at rest…partial agonists
during activity…antagonists
2
Q
{pure antagonists}
A
propranolol
3
Q
BBs w/ ISA
A
**pindolol
acebutolol
4
Q
ISA effects
A
may prevent profound bradycardia or negative inotropy in resting heart
may be disadvantageous in context of secondary prevention of MI
5
Q
Since parasympathetic activity prevails in resting heart, BBs have minimal activity on resting heart.
But some individuals may experience bradycardia in resting heart
A
may want to use BBs w/ ISA for these pts
